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Visar resultat 1 - 5 av 26 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Neurotoxicity of β-lactam antibiotics : experimental kinetic and neurophysiological studies

   Författare :Silvia E. Schliamser; Ragnar Norrby; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; benzylpenicillin; blood-brain barrier; ß-lactam antibiotics; CSF; CNS; EEG; imipenem cilastatin; FCE 22101; meningitis; neurotoxicity of; silent-second; thiopental; transport system; uraemia;

   Sammanfattning : The neurotoxic potential of intravenous administered benzylpenicillin (BPC) was studied in rabbits with intact blood-CNS barriers and rabbits with experimental E. coli meningitis. At onset of epileptogenic EEG activity or seizures, serum, CSF and brain tissue were collected for assay of BPC. LÄS MER

3. 2. Antibacterial Effect and Inflammatory Response in Relation to Antibiotic Treatment of Sepsis

   Författare :Paul Skorup; Jan Sjölin; Miklós Lipcsey; Kristoffer Strålin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sepsis; Septic shock; Antibiotics; Aminoglycoside; β-lactam; Bacteria; E. coli; Inflammation; Cytokines; Endotoxin; Porcine; ICU; Secondary sepsis; Endotoxin-tolerance.; Infektionssjukdomar; Infectious Diseases;

   Sammanfattning : Sepsis defines as life-threatening organ dysfunction caused by a dysregulated host response to infection. The importance of early administration of antibiotics in septic shock is undisputed, but the optimal antibiotic choice remains uncertain. LÄS MER

4. 3. Prognostic assessment in community acquired pneumonia

   Författare :Richard Dwyer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :β-lactam;

   Sammanfattning : Community acquired pneumonia (CAP) is the most commonly occurring infectious disease that requires hospital admission. CAP affects mainly, the youngest, the oldest, the poorest and the sickest. Annual incidence is 5-12 per 1000 adults. Between 20% and 40% of patients with CAP need in-hospital treatment. LÄS MER

5. 4. Synthesis and biological evaluation of Bicyclic β-Lactams and 2-Pyridinones : Pilicides Targeting Pilus Biogenesis in Pathogenic Bacteria

   Författare :Hans Emtenäs; Ulf Nilsson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; β-lactam; 2-pyridinone; 2-pyridone; Meldrum’s acid; Δ2-thiazoline; solid-phase synthesis; microwave assisted synthesis; antibacterial; pili; pilicide; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : New methods have been developed for the synthesis of bicyclic β-lactams and 2-pyridinones by combining acyl Meldrum’s acids and Δ2-thiazolines. The 2-pyridinones were synthesised both in solution using conventional heating or microwave assisted heating as well as by solid supported chemistry. LÄS MER

7. 5. Chromosomal β-lactamases in enterobacteria and in vivo evolution of β-lactam resistance

   Författare :Sven Bergström; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram negative bacteria; ß-lactamase genes; divergence of neighbouring cperons; ß-lactamase hyperproduction; evolution of control sequences;

   Sammanfattning : The ß-lactam antibiotics are the most important antibacterial agents in the treatment of infectious diseases. A severe problem in ß-lactam therapy is the emergence of ß-lactam resistant bacteria. Clinical ß-lactam resistance is most often due to the production of ß-lactamases. ß-lactamase genes reside either on plasmids or on the chromosome. LÄS MER