Sökning: "β-cells"

Visar resultat 11 - 15 av 143 avhandlingar innehållade ordet β-cells.

  1. 11. The Tyrosine Kinase GTK : Signal Transduction and Biological Function

    Författare :Cecilia Annerén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Protein tyrosine kinases; GTK; SHB; proliferation; survival; differentiation; β cells; pancreatectomy; cytokines; diabetes; PC12 cells; NGF; streptozotocin; focal adhesion kinase; RAP1; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Protein tyrosine kinases play an important role in the regulation of various cellular processes such asgrowth, differentiation and survival. GTK, a novel SRC-like cytoplasmic tyrosine kinase, was recently cloned from a mouse insulinoma cell line and the present work was conducted in order to find a biological function of GTK in insulin producing and neuronal cells. LÄS MER

  3. 12. Studies on free amino acids in the pancreatic β-cells

    Författare :Erik Gylfe; Umeå universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  4. 13. Mitochondrial form and function in pancreatic β-cells and brown adipocytes

    Författare :Jakob D Wikström; Jan Nedergaard; Roberta Gottlieb; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitochondria; beta cells; brown adipose tissue; diabetes; obesity; Physiology; Fysiologi; fysiologi; Physiology;

    Sammanfattning : This thesis is focused on the role of mitochondria in pancreatic β-cells and brown adipose tissue (BAT). Two main aspects of mitochondria were explored; mitochondrial functional efficiency and the interrelationship between mitochondrial shape and function. LÄS MER

  5. 14. Role of Cell-cell Interactions and Palmitate on β-cells Function

    Författare :Azazul Islam Chowdhury; Peter Bergsten; Gunilla Westermark; Peter Jones; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolism; PI3K; Pseudoislets; Human islets; SOCS; PIAS; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : The islets of Langerhans secrets insulin in response to fluctuations of blood glucose level and efficient secretion requires extensive intra-islet communication. Secretory failure from islets is one of the hallmark in progression of type 2 diabetes. LÄS MER

  7. 15. Regulation of docking and priming in pancreatic α- and β-cells

    Författare :Muhmmad Omar-Hmeadi; Sebastian Barg; Patrick MacDonald; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type-2 diabetes; glucagon; insulin; somatostatin; exocytosis;

    Sammanfattning : The secretion of islet hormones from endocrine cells of the pancreas plays vital roles in maintaining glucose homeostasis. Dysfunction of these cells leads to diabetes, a devastating metabolic disorder affecting millions worldwide, but underlying mechanisms remain poorly understood. LÄS MER