Sökning: "β-catenin"

Visar resultat 16 - 20 av 73 avhandlingar innehållade ordet β-catenin.

1. 16. A genome-wide screen for essential genes that controls the formation of human heart progenitors

   Författare :Jiejia Xu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The heart is a complex organ system composed of multiple types of tissues. These tissues are produced by a diverse set of muscle and non-muscle cells, originated from a few pools of progenitors. LÄS MER

3. 17. Mechanisms of therapy resistance in acute lymphoblastic leukemia

   Författare :Kinjal Shah; Avdelningen för translationell cancerforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALL; B-ALL; T-ALL; dexamethasone; FLT3; Signaling pathways; BCL2; resistance; PLK1; synergy;

   Sammanfattning : Acute lymphoblastic leukemia (ALL) is a highly aggressive pediatric cancer that can affect both B cells and T cells. The advent of new therapies has increased the cure rates for both B-ALL and T-ALL patients. However, some patients still experience relapse with a variable response to the treatment and display poor survival. LÄS MER

4. 18. A frizzled quest to dissect the molecular pharmacology of WNT signaling : from biology to signaling mechanism(s)

   Författare :Elisa Arthofer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The wingless/int1 (WNT)/Frizzled (FZD) family of signal transduction pathways is highly conserved across species and controls essential physiological functions important for embryonic development, stem cell renewal, proliferation, differentiation, and cell polarity. Dysregulation of these signaling pathways leads to developmental abnormalities or other conditions such as inflammation, cancer, or neurological disorders. LÄS MER

5. 19. Developmental exposure to mixtures of environmental pollutants : Studies on metabolism, developmental processes, and reproductive organs in zebrafish and chicken embryos

   Författare :Anna Mentor; Maria Jönsson; Patrick Babin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mixtures; Developmental toxicology; Endocrine disrupting chemicals; Metabolism; Feminization; Zebrafish; Chicken embryo; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

   Sammanfattning : Humans and wildlife are continuously exposed to mixtures of environmental pollutants. Mixture toxicity can be challenging to predict due to interactions between chemicals and thus whole-mixture approaches are crucial in toxicology. LÄS MER

7. 20. WNT signaling in microglia : WNTs as novel regulators of microglia

   Författare :Carina Halleskog; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Microglia, the immunocompetent cells of the central nervous system (CNS) and the brain’s own macrophages are the most motile cells in the CNS and those with highest plasticity, as they rapidly move their projections to actively screen their environment for any type of injury. Upon cell damage or infection, microglia respond quickly: they proliferate, change morphology from ramified to amoeboid state to migrate or invade towards the injury, secrete many types of cytokines and chemokines to communicate with other inflammatory cells, and phagocytose cell debris. LÄS MER