Sökning: "α1-microglobulin"

Hittade 5 avhandlingar innehållade ordet α1-microglobulin.

  1. 1. α1-microglobulin – Therapeutic opportunities in kidney and erythrocyte pathology

    Författare :Amanda Kristiansson; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; α1-microglobulin; oxidative stress; kidneys; heme; Red blood cells; hemolysis; radiation;

    Sammanfattning : Oxidative stress is defined as an imbalance between oxidants and antioxidants. The reasons behind the condition are diverse, and can result in, or contribute to, the severity of many diseases. The body has different protective mechanisms to reduce the oxidative burden, among them a protein called α1-microglobulin (A1M). LÄS MER

  3. 2. A1M: a heme and radical binding protein. A study on structure, function and mechanisms

    Författare :Sigurbjörg Rutardottir; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; α1-microglobulin; oxidative stress; heme; radiation; reactive oxygen species; preeclampsia;

    Sammanfattning : This thesis describes functional and structural studies of the human protein α1-microglobulin (A1M), an evolutionarily well-conserved 26 kDa plasma and tissue protein mainly synthesized in the liver. A1M belongs to the lipocalin protein family. Lipocalins share a very similar structur, an 8-stranded β-barrel forming a hydrophobic pocket. LÄS MER

  4. 3. Therapeutic opportunities of alpha-1-microglobulin A study in placenta, blood, skin and eye

    Författare :Martin Cederlund; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reactive oxygen species; hemoglobin; myeloperoxidase; oxidative stress; α1-microglobulin;

    Sammanfattning : This thesis describes functional studies of the human protein alpha-1-microglobulin (A1M), with the aim of exploring its usefulness as a therapeutic agent in diseases where oxidative stress is a prominent feature. A1M is a 26 kDa plasma and tissue protein with reductase activity and radical- and heme-binding antioxidative functions. LÄS MER

  5. 4. Production of human heme-binding proteins in plants for potential pharmaceutical and nutritional uses

    Författare :Magnus Carlsson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Plants have a long history as a source of nutrition and medication. In the last few decades, interest has also emerged in using plants as a production system for protein pharmaceuticals, in part due to possible scale-up- and safety-benefits with this method of production. LÄS MER

  7. 5. New predictive and diagnostic biomarkers for preeclampsia

    Författare :Ulrik Dolberg Anderson; Lund Obstetrik och gynekologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Abstract Preeclampsia is a serious pregnancy complication that affects 3-8% of all pregnancies leading to maternal- and fetal morbidity and mortality. The etiology is still not known in detail. Previous findings have shown an up regulation of the genes coding for fetal hemoglobin (HbF) in preeclamptic placentas. LÄS MER