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  1. 1. Expression and function of Suppressor of zeste 12 in Drosophila melanogaster

    Författare :Sa Chen; Åsa Rasmuson-Lestander; Jan Larsson; Mattias Mannervik; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Epigenetics; histone; polycomb; Drosophila; Suppressor of zeste 12; Genetics; Genetik; genetik; Genetics;

    Sammanfattning : The development of animals and plants needs a higher order of regulation of gene expression to maintain proper cell state. The mechanisms that control what, when and where a gene should (or should not) be expressed are essential for correct organism development. LÄS MER

  2. 2. Regulation and function of Pax-6 during head and eye development in Drosophila melanogaster

    Författare :Linn Jacobsson; Åsa Rasmuson-Lestander; Uwe Walldorf; Umeå universitet; []
    Nyckelord :molekylärbiologi; Molecular Biology;

    Sammanfattning : In Drosophila melanogaster, eyeless and twin of eyeless have important function during eye development. Mutants of both genes give a variety of eye and head phenotypes with the strongest being almost headless meaning that they lack all structures derived from the eye-antennal disc. LÄS MER

  3. 3. Genetic analysis of genes found on the 4th chromosome of Drosophila - emphasizing the developmental context of Pax6

    Författare :Jesper Kronhamn; Åsa Rasmuson-Lestander; Kevin Moses; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Pax6; twin of eyeless; headless flies; head development; eye development; eyeless; Minute; RpS3A; regulatory region; Drosophila; Genetik; Genetics; Genetik; Genetics; genetik;

    Sammanfattning : The small size and the lack of recombination set the fourth chromosome of Drosophila melanogaster apart from the other chromosomes. I have shown that the Minute gene on chromosome 4, earlier named Minute-4, encodes the ribosomal protein RpS3A. Two Pax6 genes, eyeless (ey) and twin of eyeless (toy) are also located on chromosome 4. LÄS MER

  4. 4. Harnessing the power of model systems to investigate regulation of Anaplastic Lymphoma Kinase function

    Författare :Patricia Mendoza-Garcia; Ruth Palmer; Jan Larsson; Åsa Rasmuson Lestander; Stefan Luschnig; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RTK; ALK; Drosophila; Danio rerio; ALKALs; signal transduction; transcription factor; visceral mesoderm; iridophores; neural crest; molekylärbiologi; Molecular Biology;

    Sammanfattning : The anaplastic lymphoma kinase (ALK), initially identified as a translocation partner in anaplastic large cell lymphoma (ALCL), has been described in a number of tumors such as neuroblastoma. Neuroblastoma is a neural crest derived malignancy of the sympathetic nervous system. LÄS MER

  5. 5. Regulatory proteins and the regulation of immune response in Drosophila melanogaster

    Författare :Erik Roos; Åsa Rasmuson-Lestander; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : Insect antibacterial peptides are regulated at the transcriptional level. The otherwise silent antibacterial Cecropin genes are strongly induced upon bacterial challenge. LÄS MER