Sökning: "?H2AX"
Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet ?H2AX.
1. The Importance of Dosimetry and Radiobiology in Nuclear Medicine : Quantitative methods and modelling
Sammanfattning : Nuclear medicine uses radioactive pharmaceuticals for diagnostic or therapeutic purposes. The ionizing radiation emitted from the radiopharmaceutical is partially absorbed within the patient's body and internal dosimetry is the method to estimate the absorbed dose to a tumour or risk organ. LÄS MER
2. DNA Damage Response of Normal Epidermis in the Clinical Setting of Fractionated Radiotherapy : Evidence of a preserved low-dose hypersensitivity response
Sammanfattning : Investigations of DNA damage response (DDR) mechanisms in normal tissues have implications for both cancer prevention and treatments. The accumulating knowledge about protein function and molecular markers makes it possible to directly trace and interpret cellular DDR in a tissue context. LÄS MER
3. Small-Scale Dosimetry for the Testis: Applications in Nuclear Medicine Diagnostics and Therapy
Sammanfattning : It is well known that the testicles are among the most radiosensitive tissue, and constitute an important critical target for both external and internal radiation during diagnostic and therapeutic use of radionuclides. In systemic radionuclide therapy where very high activities are administered, the testis may become a dose-limiting organ; often with a complex, non-uniform activity distribution and a resulting non-uniform absorbed-dose distribution. LÄS MER
4. WRAP53β and scaRNA2 on their journey to repair the DNA
Sammanfattning : WRAP53β is a multifunctional protein involved in several cellular processes like Cajal body formation, telomere maintenance and DNA repair. WRAP53β is responsible for targeting factors to specific cellular locations, and its very high affinity for the scaRNAs could implicate these molecules in similar biological functions. LÄS MER
5. Unwrapping the role of WRAP53β in DNA damage response
Sammanfattning : WRAP53β is a WD40 domain protein with multifaceted capabilities in several biological processes in different cellular compartments. This includes transportation of the Survival of motor neuron (SMN) complex, small Cajal body-specific (sca) RNAs and the telomerase enzyme to Cajal bodies, as well as targeting of the E3 ligase RNF8 to DNA double-strand breaks (DSBs). LÄS MER