Sustainable methods for the preparation of diverse Au(I) complexes

Sammanfattning: Over the last three decades, the role of Au(I) complexes has become increasingly important within medicinal chemistry, material applications and synthesis. Alas, their preparation remains reliant on harsh reaction conditions, hazardous solvents, exogenous additives and, often, high reaction temperatures. Within this thesis we develop mild, sustainable, methods for the preparation of Au(I) complexes, that takes place in ambient conditions and omits the use of hazardous solvents. These goals are realized in two different manuscripts. The first manuscript utilizes a nucleophilic borate to afford Au(I) aryl complexes in green solvents without the requirement for exogenous additives. Purification consists of a simple filtration and washing step and affords products in very good to excellent yields for most examples. The second manuscript employs a mechanochemical protocol for expedient preparation of Au(I) aryl complexes from a number of parent aryl sources such as borates, arenes and heteroarenes. This includes the first mechanochemical preparation of Au(I) aryl complexes from borate or hetroarene sources. The developed mechanochemical C-H auration protocols allow for significantly less acidic C-H bonds than previously reported.