Nucleoside H-phosphonates and H-phosphonothioates : some chemical and stereochemical studies

Sammanfattning: Phosphonic acid's reaction towards sterically hindered acyl chlorides has been investigated. A new synthetic method for the synthesis of nucleoside Hphosphonate monoesters has been developed. Furthermore, a method for the synthesis of nucleoside H-phosphonothioate monoesters has also been developed. Some chemical and stereochemical aspects of ribonucleoside Hphosphonate and H-phosphonothioate synthesis have been studied. Three new reagents are described, which oxidize nucleoside H-phosphonates and Hphosphonothioates into corresponding phosphates, thiophosphates and selenophosphates.