Analytical and pharmacological studies of cyclophosphamide

Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Laboratory Medicine

Sammanfattning: Pharmacokinetic and pharmacodynamic studies are an essential in order to achieve better treatment efficacy and less drug related toxicity. The kinetic studies depend on measuring the drug concentrations in body fluids. Analytical methods, sampling methods and sample preparation are important factors that affect the drug assay and hence the drug concentrations. This subsequently may alter the accuracy of pharmacokinetic and pharmacodynamic investigations. Cyclophosphamide (CPA) is an anticancer drug, which is widely used for the treatment of hematological malignancies as well as solid tumors. It is a prodrug that undergoes complicated process of metabolic activation and inactivation in the liver. Many bioanalytical assays for the quantification of CPA and its metabolites have been developed over the past decade. However, these methods have several limitations including long analysis time, sample preparation and large sample volume. The aim of the present studies was to develop a new sensitive analytical method for cyclophosphamide and subsequently to use this method for evaluattion of new sampling

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