Sökning: "zymography"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet zymography.

  1. 1. Matrix metalloproteinases in natural killer cells. Expression of MMPs, IL-2 activation and killer cell interactions with Matrigel® and model tumours

    Författare :Per Albertsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protease; matrix metalloproteinase; killer cell; IL-2; Matrigel; B16 melanoma; tumour infiltration; invasion assay; zymography; Western blot; RT-PCR; light microscopy; fluorescence; electron microscopy;

    Sammanfattning : Introduction: IL-2 activated natural killer (A-NK) cells can recognize malignant cells and exert tumouricidal activities by multiple mechanisms that require close contact with the target cells. Upon adoptive transfer, some A-NK cells accumulate in tumours by migrating from the vascular bed to a position inside the malignant tissue, forming close contacts with target cells. LÄS MER

  3. 2. The road from atherosclerosis to myocardial infarction : studies in an experimental model

    Författare :Anne-Louise Hemdahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Atherosclerosis; myocardial infarction; ischemia; hypoxia; matrix metalloproteinase; remodelling; electrocardiogram; gene expression; inflammation;

    Sammanfattning : Atherosclerosis is a slow progressing disease with continuous lipid deposition and inflammation in the arterial wall. Stenotic arteries may cause angina pectoris but it is the sudden formation of an occluding thrombosis on the atherosclerotic plaque that leads to myocardial infarction. LÄS MER

  4. 3. Joint disease biomarkers - discovery and application

    Författare :Dovilė Sinkevičiūtė; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoarthritis; Psoriatic arthritis; cartilage; Proteomics; Biomarkers; ELISA; Tissue culture; Extracellular matrix ECM ;

    Sammanfattning : Dysregulated cartilage homeostasis, articular cartilage degradation and abnormal bone remodeling are common denominators in joint disease and can lead to severe disability for the patients. The molecular pathways behind the disease pathology can overlap across different joint diseases. LÄS MER

  5. 4. The prostanoid FP receptor and uveoscleral outflow : A study of FP receptor expression and functions in the eye

    Författare :Anette Ocklind; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Prostanoid FP receptor; tissue distribution; ciliary muscle; iris sphincter muscle; extracellularmatrix; actin; prostaglandin F2a; latanoprost; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Prostaglandin F2α is a prostanoid FP receptor agonist which acts as an intraocular pressure-lowering agent by increasing the uveoscleral outflow of aqueous humour through the ciliary muscle. The aim of this, thesis was to investigate possible mechanisms of the increased uveoscleral outflow induced by prostaglandin F2α and its analogue latanoprost acid. LÄS MER

  7. 5. Studies of chronic ulcers and larval therapy

    Författare :Helene Wolff; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic ulcers; wounds; larval therapy maggot; MRSA; debriding; proteases; larval therapy; maggot; debriding. proteases;

    Sammanfattning : Our aims in this study were to learn more about chronic ulcer pathogenesis (Paper I) and larval therapy (Paper II-V).Materials and methods: Paper I: 26 bacterial isolates of P. aeruginosa from chronic ulcers were examined by PCR technique for detection of the genes of two virulence factors (elastase and alkaline proteinase). LÄS MER