Sökning: "von Willebrand factor."

Visar resultat 1 - 5 av 47 avhandlingar innehållade orden von Willebrand factor..

  1. 1. Genetic characterization of families with von Willebrand disease

    Författare :Elsa Lanke; Malmö Klinisk koagulationsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mutation; bleeding; coagulation; von Willebrand disease; genetics;

    Sammanfattning : von Willebrand disease (VWD) is the most common hereditary bleeding disorder. It is caused by quantitative and/or qualitative defects of the von Willebrand factor (VWF). The severity of the disease can vary considerably, as can the hereditary patterns. LÄS MER

  3. 2. Biomarkers and risk of intracerebral hemorrhage : population-based studies in northern Sweden

    Författare :Kristina Johansson; Marcus Lind; Lars Johansson; Jan-Håkan Jansson; Arne Lindgren; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intracerebral hemorrhage; hemorrhagic stroke; factor XII; D-dimer; von Willebrand factor; ABO blood groups; phosphatidylethanol; alcohol; risk markers; biomarkers; Medicine; medicin;

    Sammanfattning : BackgroundIntracerebral hemorrhage (ICH) is a disease associated with a high morbidity and mortality and treatment options for the condition are limited. Even though an ICH event usually comes as a surprise to the affected individual, pathogenetic processes often have occurred before the sudden ICH event and may have preceded disease onset by years. LÄS MER

  4. 3. Studies of the pathogenesis of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura

    Författare :Diana Karpman; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatri; Pediatrics; tumor necrosis factor; interleukin 6; von Willebrand factor; apoptosis; lipopolysaccharide; shiga-like toxin; Escherichia coli O157:H7; Hemolytic uremic syndrome; thrombotic thrombocytopenic purpura; Urology; nephrology; Urologi; nefrologi;

    Sammanfattning : This study investigated the pathogenesis of hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). (1) The relative roles of lipopolysaccharide and Shiga-like toxin-2 were studied in a mouse model of Escherichia coli O157:H7 infection. LÄS MER

  5. 4. Endothelial and cardiac effects of 5-fluorouracil. An experimental and clinical study

    Författare :Sara Kinhult; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Cytology; endothelin; onkologi; Cytologi; cancer; von Willebrand factor; thrombomodulin; lipoperoxidation; probucol; low-molecular weight heparin; scanning electron microscopy; 5-fluorouracil; endothelium;

    Sammanfattning : The cytostatic drug 5-fluorouracil (5-FU) has been shown to affect both morphology and function of vascular endothelium. These effects could be part of the pathophysiology for 5-FU induced cardiotoxicity. The present thesis explores the mechanisms of this endothelial toxicity. LÄS MER

  7. 5. Binding of plasma proteins by Staphylococcus epidermidis: characterisation of protein-protein interactions

    Författare :Dai-Qing Li; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; mice and immunisation; biomaterial-associated infections; von Willebrand factor; thrombospondin; clusterin; Staphylococcal receptins; vitronectin; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Coagulase-negative staphylococci (CoNS), in particular, Staphylococcus epidermidis, have emerged as major nosocomial pathogens associated with infections of implanted medical devices. These organisms, which are among the most prevalent bacteria of the human skin and mucous membrane microflora, gain access to the surface of the implant at the insertion. LÄS MER