Sökning: "voltage sensor domain"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden voltage sensor domain.

  1. 1. Dynamics of the voltage-sensor domain in voltage-gated ion channels : Studies on helical content and hydrophobic barriers within voltage-sensor domains

    Författare :Christine S. Schwaiger; Erik Lindahl; Lynn Kamerlin; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; activation; deactivation; inactivation; voltage-sensor; VSD; Kv1.2- 2.1; F233; hydrophobic barrier; alpha-helix; 3 10 -helix; Biological physics; Biologisk fysik;

    Sammanfattning : Voltage-gated ion channels play fundamental roles in neural excitability and thus dysfunctional channels can cause disease. Understanding how the voltage-sensor of these channels activate and inactivate could potentially be useful in future drug design of compounds targeting neuronal excitability. LÄS MER

  3. 2. Membrane Induced Structure in Transmembrane Signaling Proteins and Peptides : Peptide–Lipid Interactions Studied by Spectroscopic Methods

    Författare :Sofia E. Unnerståle; Lena Mäler; Jason Schnell; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; peptide-lipid interaction; paddle domain; voltage gating; voltage sensor domain; micelle; phospholipid bicelle; solution structure; HAMP domain; nuclear magnetic resonance spectroscopy; circular dichroism spectroscopy; nonspecific interaction; Biophysics; biofysik;

    Sammanfattning : Biological membranes, defining the boundary of cells and eukaryotic organelles, are mainly composed of lipids and membrane proteins. Interactions between these lipids and proteins are needed to preserve the tight seal of the membrane, but also to induce structure for proper function in many membrane proteins. LÄS MER

  4. 3. Voltage sensor activation and modulation in ion channels

    Författare :Christine S Schwaiger; Lindahl Erik; Paolo Carloni; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; activation; deactivation; inactivation; voltage sensor; VSD; gating; Kv1.2-2.1; Shaker; F233; hydrophobic barrier;

    Sammanfattning : Voltage-gated ion channels play fundamental roles in neural excitability, they are for instance responsible for every single heart beat in our bodies, and dysfunctional channels cause disease that can be even lethal. Understanding how the voltage sensor of these channels function is critical for drug design of compounds targeting neuronal excitability. LÄS MER

  5. 4. Molecular aspects on voltage-sensor movement

    Författare :Amir Broomand; Fredrik Elinder; Guiscard Seebohm; Linköpings universitet; []
    Nyckelord :Potassium channels; voltage-gated; chemistry; metabolism; physiology; patch-clamp techniques; oocytes; MEDICINE; MEDICIN;

    Sammanfattning : Voltage-gated ion channels are fundamental for electrical signaling in living cells. They are composed of four subunits, each holding six transmembrane helices, S1-S6. Each subunit contains a voltage-sensor domain, S1-S4, and a pore domain, S5-S6. LÄS MER

  7. 5. Voltage sensor movements in shaker and HCN channels

    Författare :Roope Männikkö; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Voltage-gated ion channels are crucial for electrical signaling in living organisms. They are composed of four similar subunits with six transmembrane α-helices, S1-S6. Each subunit contains a voltage-sensing domain, S1-S4, and an ion-conducting pore domain, S5-S6. LÄS MER