Sökning: "vesicle aggregation"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden vesicle aggregation.

  1. 1. Pathogenic effects of alpha-synuclein: modifications and toxicity

    Författare :Natalie Landeck; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Nyckelord :Parkinson s disease; adeno-associated viral vector; animal models; alpha-synuclein; substantia nigra; dopaminergic neurons; phosphorylation; aggregation; toxicity;

    Sammanfattning : Accumulation of intraneuronal inclusions, containing mainly a protein called alpha-synuclein (asyn), is thought to play a critical role in neurodegenerative disorders such as Parkinson's disease (PD). In these so called Lewy bodies, the majority of asyn is phosphorylated at serine 129 (pS129) suggesting that post-translational modifications may play a critical role in the process of aggregate formation. LÄS MER

  3. 2. Interactions of the Cell-Penetrating Peptide Penetratin with Model Membranes and Live Cells

    Författare :Daniel Persson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antisense; antennapedia homeodomain; delivery vector; cell-penetrating peptide; protein transduction; uptake; membrane translocation; penetratin; confocal microscopy; vesicle;

    Sammanfattning : The delivery of large, hydrophilic molecules, such as proteins and oligonucleotides, to the cytoplasm and nucleus of cells is problematic due to their generally low plasma membrane permeability. With the identification of a number of cell-penetrating peptides, capable of mediating non-endocytotic, intracellular delivery of macromolecular cargos, this obstacle now seems surmountable. LÄS MER

  4. 3. Studies of the interaction of penetratin with phospholipid vesicles

    Författare :Per Thoren; Daniel Persson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane translocation; vesicle aggregation; cell-penetrating peptides; cellular uptake; Antennapedia homeodomain; circular dichroism; membrane binding; penetratin;

    Sammanfattning : .... LÄS MER

  5. 4. Aggregation behavior and peptide-lipid interaction in an amyloid model system

    Författare :Jon Pallbo Arvidsson; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; amyloids; peptides; lipids; NACore; aggregation; fibrillation; crystallization; self-assembly; interaction;

    Sammanfattning : Proteins constitute a major component of living cells and are essential to their function. Sometimes proteins misfold or aggregate in abnormal ways, which can give rise to diseases. Amyloids are a special type of highly ordered protein aggregates made of long intermolecular beta-sheets stacked into fibrils. LÄS MER

  7. 5. Proteostasis beyond chaperones - Auxiliary systems in the management of damaged proteins

    Författare :Rebecca Josefson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aging; proteostasis; protein quality control; asymmetric inheritance; vesicle trafficking;

    Sammanfattning : Aging entails loss of functionality and increased risk of death, even for unicellular organisms, such as the yeast Saccharomyces cerevisiae. On a cellular level, aging is accompanied by an accumulation of harmful aging factors, e.g. damaged and aggregated proteins. LÄS MER