Sökning: "tyrosine kinases"
Visar resultat 1 - 5 av 138 avhandlingar innehållade orden tyrosine kinases.
1. The Tyrosine Kinase GTK : Signal Transduction and Biological Function
Sammanfattning : Protein tyrosine kinases play an important role in the regulation of various cellular processes such asgrowth, differentiation and survival. GTK, a novel SRC-like cytoplasmic tyrosine kinase, was recently cloned from a mouse insulinoma cell line and the present work was conducted in order to find a biological function of GTK in insulin producing and neuronal cells. LÄS MER
2. Protein tyrosine kinases in insulin producing cells : Expression and putative importance for beta-cell function
Sammanfattning : Protein tyrosine kinases are of importance for cell replication and differentiation in manysystems. The mechanisms controlling the replication and differentiation of insulin producingcells are unknown. LÄS MER
3. Protein Tyrosine Phosphatases as Regulators of Receptor Ryrosine Kinases
Sammanfattning : Tyrosine phosphorylation is a crucial mechanism in cellular signaling and regulates proliferation, differentiation, migration and adhesion. The phosphorylation reaction is reversible and is governed by two families of enzymes: protein tyrosine kinases and protein tyrosine phosphatases (PTPs). LÄS MER
4. Expression and Mutation Analyses of Candidate Cancer Genes In Situ
Sammanfattning : Cancers display heterogeneity in genetic profiles of the individual cancer cells and in the composition of different malignant and non-malignant cell populations. Such intra-tumor heterogeneity plays a role in treatment response and the emergence of resistance to cancer therapies. LÄS MER
5. Signal Transduction by Proline-Rich Tyrosine Kinase Pyk2
Sammanfattning : The proline-rich tyrosine kinase (Pyk2) together with focal adhesion kinase (FAK) define a family of non-receptor protein tyrosine kinases that are regulated by diverse stimuli. Activation of Pyk2 has been implicated in multiple signaling events, including modulation of ion channels, activation of MAP kinase cascades and apoptotic cell death. LÄS MER