Sökning: "tumour suppressor"

Visar resultat 1 - 5 av 91 avhandlingar innehållade orden tumour suppressor.

  1. 1. Functional Characterization of the Yeast Tumour Suppressor Homologue Sro7p

    Författare :Annabelle Forsmark; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Yeast; protein sorting; protein secretion; L 2 GL; tumour suppressor; SRO7; SRO77; ENA1; exocytosis; post-Golgi vesicles; ART5; E3 adaptor; ubiquitylation; ATLGL1; ATLGL2;

    Sammanfattning : Correct targeting of newly synthesized proteins to appropriate domains of the cell membrane is crucial to cellular architecture, polarity and function, making it no surprise that many proteins of the secretory machinery are conserved throughout evolution. This work presents a functional characterisation of the Saccharomyces cerevisiae cell polarity protein and tumour suppressor homologue, Sro7p. LÄS MER

  3. 2. Prognostic factors with predictive potential in breast cancer : special focus on the tumour suppressor p53

    Författare :Sigrid Sjögren; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  4. 3. Small intestinal neuroendocrine tumours - Disease models, tumour development, and remedy

    Författare :Tobias Hofving; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroendocrine tumours; tumour models; SMAD4; 177Lu-octreotate therapy; immunotherapy;

    Sammanfattning : Small intestinal neuroendocrine tumours (SINETs) are malignant neoplasms which at the time of diagnosis often present with distant metastasis. The field of SINET research faces several challenges. LÄS MER

  5. 4. Oncogenes and tumour suppressor genes in human central nervous system tumours

    Författare :Lu Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human central nervous system (CNS) tumours may arise from both developing and adult brain. Primitive neuroectodermal tumours (PNETs) are the most malignant tumours arising from developing brain, and constitute approximately one third of brain tumours in children. Other common paediatric CNS tumours are ependymomas and pilocytic astrocytomas. LÄS MER

  7. 5. Genomic instability and genetic heterogeneity in neuroblastoma tumours

    Författare :Niloufar Javanmardi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma tumour; subclone; mutation; relapse; deep sequencing; tumour supressor gene;

    Sammanfattning : Neuroblastoma (NB), a tumour of the sympathetic nervous system and the most common malignant disease of early childhood, is responsible for 9% of paediatric cancer related deaths. Aggressive NB still constitutes a major clinical problem with survival rates of about 35%. LÄS MER