Sökning: "tumor-initiating cells"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden tumor-initiating cells.

  1. 1. Hypoxia-Inducible Factors in Tumor Cell Differentiation and Tumor Vascularization

    Författare :Alexander Pietras; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-2alpha; cancer; notch; angiogenesis; tumor-initiating cells; hypoxia; neuroblastoma; differentiation;

    Sammanfattning : Mammalian cells, including tumor cells, adapt to hypoxia via stabilization of two transcription factors - Hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha. Among other consequences, hypoxia is a main driving force behind angiogenesis. LÄS MER

  3. 2. Stem and progenitor cells in brain ad breast malignancies

    Författare :Gabriella Honeth; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural progenitor cells; glioma; migration; chemokines; cancer stem cells; breast cancer; CD44; CD24;

    Sammanfattning : Stem cells have qualities that clearly distinguish them from all other cells. Capabilities like self-renewal, differentiation and migration make them truly powerful. This thesis deals with different aspects of stem/progenitor cells in relation to cancer. LÄS MER

  4. 3. Neural stam cells, TLX, and Neuroblastoma

    Författare :Ravi Kanth Rao Saini; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; TLX; Neural Stem Cells; Dedifferentiation; DISC-1; DNA-PKcs;

    Sammanfattning : Neuroblastoma (NB) is one of the most commonly diagnosed extracranial tumors in children below five years of age. Moreover, NB accounts for almost 12-15% of all childhood cancer related fatalities. To date, the origin of NB has been linked to the neural crest derived sympathoadrenal progenitor cells. LÄS MER

  5. 4. Modeling glioblastoma heterogeneity to decipher its biology

    Författare :Yuan Xie; Lene Uhrbom; Massimo Squatrito; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma multiforme; biobank; GBM cells; cell of origin; LGR5; OPCs;

    Sammanfattning : Glioblastoma multiforme (GBM) is the most common and lethal form of primary brain tumor that mainly affects adults. GBM displays remarkable intra- and inter-tumoral heterogeneity and contains a subpopulation of cells named glioma stem cells that is believed to be responsible for tumor maintenance, progression and recurrence. LÄS MER

  7. 5. Induction of epithelial-mesenchymal transition (EMT) in women's cancer : protective role of differentiation factors

    Författare :Joel Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Metastatic spread of cancer cells to vital organs is the predominant cause of death among women suffering from breast and ovarian cancer, and invasive cancer cells are in many cases resilient to standard drugs used in the clinic. Consequently, further understanding of the metastatic process and development of new strategies to target invasive cancer cells are needed. LÄS MER