Sökning: "tumor necrosis factor inhibition"

Visar resultat 1 - 5 av 32 avhandlingar innehållade orden tumor necrosis factor inhibition.

  1. 1. Aspects on inflammation and cardiovascular comorbidity in rheumatoid arthritis

    Författare :Lotta Ljung; Solbritt Rantapää-Dahlqvist; Johan Askling; Piet van Riel; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; co-morbidity; cardiovascular disease; atherosclerosis; acute coronary syndromes; adipokines; adipose tissue; tumor necrosis factor inhibition;

    Sammanfattning : There is an increased risk for cardiovascular (CV) comorbidity among patients with rheumatoid arthritis (RA), with premature atherosclerosis, and a higher incidence of CV events, compared with the general population. Disease related factors add to the CV risk, and interact with the traditional CV risk factors. LÄS MER

  3. 2. Oxygen delivery and mitochondrial dysfunction as assessed by microdialysis during interventions in experimental sepsis

    Författare :Magnus von Seth; Lipscey Miklós; Jan Sjölin; Mats Eriksson; Jukka Takala; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; animal models; microdialysis; endotoxin; Escherichia coli; tigecycline; doxycycline; albumins; capillary leak syndrome; lactic acid; oxygen delivery; multiple organ failure; mitochondria; tumor necrosis factor alpha; interleukin-6; cyanides; ouabain; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

    Sammanfattning : Early administration of broad-spectrum antibiotics is the first goal in sepsis treatment. Besides from bacteriostatic/bactericidal effects, some antibiotics may also modify the host´s response to infection. The novel antibiotic tigecycline may exert such properties; however, this property has not been evaluated in large-animal trials. LÄS MER

  4. 3. Proteasome inhibition in the regulation of natural killer cell function and multiple myeloma cell apoptosis

    Författare :Xiaoli Feng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple myeloma (MM) is a hematologic malignancy mostly occurring in the elderly and characterized by an expansion of monoclonal plasma cells in the bone marrow and increased monoclonal immunoglobulin in plasma. The outcome of this disease has been greatly improved due to introduction of new drugs. LÄS MER

  5. 4. Effects of lipid oxidation on transcriptional regulation and cell death

    Författare :Mikko Ares; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :atherosclerosis; low density lipoprotein; lipid oxidation; nuclear factor-KB; activator protein-1; Iysophosphatidylcholine; tumor necrosis factor-alpha; oxysterol; Ca2 ; apoptosis; lipid accumulation;

    Sammanfattning : Elevated levels of low density lipoprotein (LDL) in plasma are associated with an increased risk for atherosclerosis. Excessive accumulation of lipoproteins and lipids in the vascular wall is thought to lead to the development of advanced atherosclerotic lesions prone to rupture. LÄS MER

  7. 5. Modulation of the inflammatory response in experimental bacterial meningitis

    Författare :Carl Granert; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :bacteria; meningitis; adhesion; leukocytes; microcirculation; fucoidin; cytokines; tumor necrosis factor; interleukin; CNI-1493; macrophage; CNS; inflammation; experimental;

    Sammanfattning : In bacterial meningitis, tissue damage in the central nervous system (CNS) is inflicted by the host's inflammatory response to invading pathogens, rather than by the bacteria itself. Adjuvant treatment with anti-inflammatory drugs in experimental bacterial meningitis has demonstrated beneficial effects on CNS pathology. LÄS MER