Sökning: "transgenic"
Visar resultat 1 - 5 av 551 avhandlingar innehållade ordet transgenic.
1. Studies of the function of platelet-derived growth factor and glial fibrillary acidic protein in vivo : a transgenic approach
Sammanfattning : .... LÄS MER
2. Of mice and men : SOD1 associated human amyotrophic lateral sclerosis and transgenic mouse models
Sammanfattning : Amyotrophic lateral sclerosis, ALS, is a progressive fatal neurodegenerative disorder affecting motor neurones in motor cortex, brain stem and spinal cord. This inevitably leads to paralysis, respiratory failure and death. LÄS MER
3. Molecular characterization of prostate hyperplasia in prolactin transgenic mice
Sammanfattning : Benign prostatic hyperplasia (BPH) and prostate cancer are age-related diseases, affecting a majority of elderly men in the western world, and are known to be influenced by several different hormones, including sex hormones. Although the hormone prolactin (PRL) is well known to exert trophic effects on prostate cells, its involvement in the pathophysiology is still poorly characterized. LÄS MER
4. Effects of PGC1a-induced exercise adaptations in muscle on plasticity and recovery mechanisms in the CNS
Sammanfattning : In this thesis, we sought to determine if muscle-derived exercise-induced signaling via PGC-1α muscle activation influences neuroplasticity under physiological or pathophysiological conditions. For this purpose, transgenic mice with muscle-specific overexpression of PGC-1α that display an endurance exercise muscle phenotype were evaluated in models of cranial irradiation and photothrombotic stroke, as well as in aging and in a voluntary running paradigm. LÄS MER
5. Effects of growth hormone on bone tissue in transgenic mice
Sammanfattning : Growth hormone (GH) affect bone-tissue in both humans and rodents. Also sex steroids are important for growth and the maintenance of normal bone physiology. The specific aims of this study were to investigate how high levels of GH affects bone tissue in mice and to determine whether these effects are dependent on an intact gonadal function. LÄS MER