Sökning: "tissue inhibitor of metalloproteinase 1 TIMP-1"
Visar resultat 1 - 5 av 15 avhandlingar innehållade orden tissue inhibitor of metalloproteinase 1 TIMP-1.
1. Extracellular matrix remodelling proteases in acute appendicitis and their impact on appendiceal perforation
Sammanfattning : Abstract Background Appendicitis is associated with varying degradation of extracellular matrix involved in tissue injury. The principal aim of this study was to investigate whether immunoreactive techniques could illustrate the course and severity of appendicitis and separate the different inflammatory grades, phlegmonous, gangrenous and perforated appendicitis, from each other and from uninflamed appendix. LÄS MER
2. Migration on extracellular matrix surface and infiltration into matrix - two distinguishable activities of human T cells
Sammanfattning : Migration of T-lymphocytes on a surface coated with extracellular matrix (ECM) components (two-dimensional (2-D) migration) and migration (infiltration) into a matrix (Three-dimesional (3-D) migration) are complex events and the underlying mechanisms are not yet fully understood. Here 2-D and 3-D migration were studied by use of seven leukemic T-cell lines representing discrete differentiation stages, a non-leukemic T-cell clone, and normal peripheral blood T cells. LÄS MER
3. Rectal Cancer - Tumor Biology and Prognostic Markers
Sammanfattning : Colorectal cancer is one of our most common malignancies and the second leading cause of cancer death worldwide. About 1/3 of the tumors are located in the rectum. LÄS MER
4. Inflammatory Markers, Respiratory Diseases, Lung Function and Associated Gender Differences
Sammanfattning : Systemic inflammation is associated with impaired lung function. Inflammation is part of asthma and chronic obstructive pulmonary disease (COPD), but the local and systemic inflammatory pattern differs. LÄS MER
5. Remodelling of extracellular matrix in rectal cancer and preoperative radiotherapy
Sammanfattning : BACKGROUND Preoperative radiotherapy reduces local recurrence due to rectal cancer, but increases postoperative morbidity. The aim of this thesis was to study the impact of radiotherapy on extracellular matrix (ECM) remodelling enzymes and growth factors after radiotherapy and also their possible use as surrogate markers for complications. LÄS MER