Sökning: "thiopurine methyltransferase"

Visar resultat 6 - 8 av 8 avhandlingar innehållade orden thiopurine methyltransferase.

1. 6. Interindividual differences in thiopurine metabolism : studies with focus on inflammatory bowel disease

   Författare :Sofie Haglund; Sven Almer; Jan Söderman; Curt Peterson; Åke Nilsson; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : The thiopurines, 6-mercaptopurine and its prodrug azathioprine, are used in the treatment of inflammatory bowel disease, ulcerative colitis and Crohn´s disease. The main active metabolites are the phosphorylated thioguanine nucleotides (6-TGNs) and methylated thioinosine monophosphate (meTIMP). LÄS MER

3. 7. Pharmacological and molecular investigations on the mechanisms underlying resistance of human leukaemia cells to the antimetabolites methotrexate, 6-mercaptopurine and 6-thioguanine

   Författare :Alan Kambiz Fotoohi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The goal of this thesis has been to elucidate the mechanisms underlying resistance to methotrexate (MTX), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG), the antimetabolites widely used in treatment of childhood leukemia, as well as to determine the influence of 7-hydroxymethotrexate (7-OHMTX), the major metabolite of MTX, on the therapeutic action of MTX. Resistant sublines of leukemic cell lines were developed by long-term exposure to stepwise increasing concentrations of these different agents. LÄS MER

4. 8. Pharmacological studies on uptake, metabolism, and resistance to anti-cancer drugs : insights into the treatment of leukemia

   Författare :Hazhar Karim; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Leukemia is blood cancer that begins in the bone marrow and characterized by abnormal production of white blood cells. Due to advances in treatment, there has been a dramatic increase in survival rate for patients with different types of leukemia. LÄS MER