Sökning: "thiopurine methyltransferase"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden thiopurine methyltransferase.

  1. 1. Pharmacogenetic studies of thiopurines focus on thiopurine methyltransferase

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Malin Lindqvist Appell; Linköpings universitet.; Linköpings universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Sammanfattning : Pharmacogenetics represents the study ofvariability in drug response due to genetic variations. The thiopurines (6-mercaptopurine, 6-thioguanine and azathioprine) are prodrugs which require metabolic transformation to exert effect. LÄS MER

  2. 2. Biophysical Characterization of Thiopurine S-Methyltransferase : A Key enzyme in the Effects of Thiopurine Drugs

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Patricia Wennerstrand; Linköpings universitet.; Linköpings universitet.; [2012]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : In the treatment of leukemia and inflammatory bowel disease, thiopurines are commonly used drugs. Thiopurine S-methyltransferase (TPMT) is one of the drug metabolizing enzymes responsible of counteracting the formation of TGNs that will be incorporated into the DNA and RNA synthesis and thus induce apoptosis. LÄS MER

  3. 3. Clinical studies of thiopurine metabolism in inflammatory bowel disease

    Detta är en avhandling från Division of Gastroenterology, Department of Clinical Sciences, Faculty of Medicine, Lund University

    Författare :Ulf Hindorf; Lunds universitet.; Lund University.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastroenterologi; Gastro-enterology; thiopurine methyltransferase; 6-mercaptopurine; azathioprine; Inflammatory bowel disease; thiopurines; adverse events; methylated metabolites; thioguanine nucleotides;

    Sammanfattning : Inflammatory bowel disease (IBD, i.e. primarily Crohn's disease and ulcerative colitis) is characterised by a chronic or relapsing inflammation of the digestive tract. LÄS MER

  4. 4. Thiopurine S-methyltransferase - characterization of variants and ligand binding

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Annica Blissing; Linköpings universitet.; Linköpings universitet.; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Thiopurine S-methyltransferase TPMT ; protein stability; enzyme kinetics; ligand binding; isothermal titration calorimetry ITC ; 8-anilinonaphthalene-1-sulfonic acid ANS ;

    Sammanfattning : Thiopurine S-methyltransferase (TPMT) belongs to the Class I S-adenosylmethionine-dependent methyltransferase (SAM-MT) super family of structurally related proteins. Common to the members of this large protein family is the catalysis of methylation reactions using S-adenosylmethionine (SAM) as a methyl group donor, although SAM-MTs act on a wide range of different substrates and carry out numerous biologically important functions. LÄS MER

  5. 5. Interindividual differences in thiopurine metabolism studies with focus on inflammatory bowel disease

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Sofie Haglund; Linköpings universitet.; Linköpings universitet.; Östergötlands Läns Landsting.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Sammanfattning : The thiopurines, 6-mercaptopurine and its prodrug azathioprine, are used in the treatment of inflammatory bowel disease, ulcerative colitis and Crohn´s disease. The main active metabolites are the phosphorylated thioguanine nucleotides (6-TGNs) and methylated thioinosine monophosphate (meTIMP). LÄS MER