Sökning: "thiazolidinedione"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet thiazolidinedione.

  1. 1. Development of sensitive cellular assay systems and their application to the identification of "orphan" seven-transmembrane receptors

    Författare :Knut Kotarsky; Slemhinnans immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biokemi; Metabolism; Biochemistry; metabolism; leukotrieneB4; thiazolidinedione; 9-HODE; fatty acid; luciferase; GFP; reporter gene; preclinical assay; receptor; GPCR;

    Sammanfattning : Seven-transmembrane, G-protein coupled receptors play a central role in physiology since they facilitate cell communication in multicellular organisms by recognition of a broad range of ligands. They also represent important drug targets. LÄS MER

  3. 2. Discovery of Novel Receptors for Lipid Mediators - a study leading to the identification of receptors involved in metabolism and the immune system

    Författare :Niclas Nilsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; Clinical biology; Thiazolidinedione; SCFA; FFA; FFA2R; FFA1R; GPR43; GPR41; GPR40; BLT2; GPCR; Orphan; Receptor;

    Sammanfattning : Intercellular communication is of crucial importance in regulating physiology and G-protein coupled receptors (GPCRs) have evolved as an important mechanism in this process. Of the approximately 800 human GPCRs, about 160 are still considered to be “orphan” receptors for which an endogenous ligand remains to be identified. LÄS MER

  4. 3. Thermal physiology and metabolism : Interplay between heat generation and energy homeostasis

    Författare :Gustavo Abreu-Vieira; Jan Nedergaard; Eric Ravussin; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fysiologi; Physiology;

    Sammanfattning : Mammal metabolism is intimately connected to the maintenance of body temperature. While metabolic pathways invariably produce heat as a by-product, the natural heat present in the environment also plays a role in defining the adaptive metabolism and general physiology of an organism. LÄS MER

  5. 4. Post-transplantation Hypercholesterolaemia

    Författare :Osama Al Rayyes; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thiazolidinediones; transplantation; low density lipoprotein; insulin; indomethacin; hydrocortisone; fluvastatin; flufenamic acid; Cholesterol; cyclosporine; troglitazone.; Immunology; serology; Immunologi; serologi;

    Sammanfattning : The multidrug regimen, cyclosporine, corticosteroids, and azathioprine, is used in transplantation centres to prevent organ rejection. Several clinical studies have shown that cyclosporine and corticosteroids to cause increases in low density lipoprotein (LDL)-cholesterol, with subsequent development of atherosclerosis. LÄS MER

  7. 5. Studies on receptors for modified LDL in human monocytes and macrophages : a link between diabetes and atherosclerosis?

    Författare :Linda Svensson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atherosclerosis; diabetes CD14; CD36; CD64; fatty acid; flow cytometry; macrophage; monocyte; scavenger receptor;

    Sammanfattning : Type 2 diabetes increases the risk for cardiovascular disease three- to fourfold. Because of the rise in diabetes prevalence there is a need for a better understanding of the link between diabetes and atherosclerosis. LÄS MER