Sökning: "target identification"

Visar resultat 1 - 5 av 360 avhandlingar innehållade orden target identification.

  1. 1. MRI in prostate cancer : implications for target volume

    Författare :Ulrika Björeland; Camilla Thellenberg-Karlsson; Tufve Nyholm; Joakim Jonsson; Lars Beckman; Taran Paulsen Hellebust; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MRI; imaging; prostate; radiotherapy; target detection; radiofysik; radiation physics;

    Sammanfattning : Prostate cancer (PCa) is the most common cancer among men, with 10 000 new cases per year in Sweden [1]. To diagnose PCa, magnetic resonance imaging (MRI) is used to identify and classify the disease. LÄS MER

  3. 2. Drug discovery against leishmaniasis : Bio- and chemoinformatic guided strategies for target evaluation and hit identification

    Författare :Elisabet Vikeved; UCM Alsmark; Christian Sköld; David Horn; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Leishmaniasis; Drug discovery; Lateral gene transfer; Comparative genomics; Virtual screening; Target fishing; Marine natural products;

    Sammanfattning : Leishmaniasis is a neglected tropical disease mainly affecting poor people in developing countries. It is caused by infections of flagellated protozoa belonging to genus Leishmania. The few available drugs are associated with problems such as low effectiveness, severe side effects and resistance development. LÄS MER

  4. 3. Drug Repositioning for Cancer Treatment : Novel Candidate Identification Strategies

    Författare :Madiha Nazir; Mårten Fryknäs; Sigurd Vitols; Uppsala universitet; []
    Nyckelord :cancer treatment; drug repositioning; Phosphodiesterase 3A PDE3A ; apoptosis; combination screening;

    Sammanfattning : Regardless of the enormous investments in cancer research and drug development, the proportion of approved drugs in oncology is low compared to other indications, and new avenues are needed. One attractive approach in this regard is drug repositioning where new uses outside the scope of the original medical indications for existing drugs are identified. LÄS MER

  5. 4. Inhibitors Targeting Insulin-Regulated Aminopeptidase (IRAP) : Identification, Synthesis and Evaluation

    Författare :Karin Engen; Mats Larhed; Mikael Elofsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; compound screening; insulin-regulated aminopeptidase; IRAP; inhibitors; cognitive disorders; spiro-oxindole; quinazolinone; imidazopyridine; medicinal chemistry; structure-activity relationship; microwave heating; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Insulin-regulated aminopeptidase (IRAP) has emerged as a potential new therapeutic target for treatment of cognitive disorders. Inhibition of the enzymatic activity facilitates cognition in rodents. LÄS MER

  7. 5. Identification of compounds that target glioma initiating cells

    Författare :Shimei Wee; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Glioblastoma multiforme is a common form of brain tumor that leads to debilitating effects despite the current regiment of treatment, which includes surgery, chemotherapy and radiotherapy. With the discovery of glioma-initiating cells (GICs) that exists within the bulk tumor, some light has been shed on this disease. LÄS MER