Sökning: "synovial tissue"

Visar resultat 1 - 5 av 87 avhandlingar innehållade orden synovial tissue.

1. 1. Genetic Profiling in Soft Tissue Sarcoma

   Författare :Princy Francis; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; synovial sarcoma; prognosis; Cytology; SS18-SSX; intratumor heterogeneity; aCGH; array comparative genomic hybridization; gene expression analysis; microarray; cDNA; Soft tissue sarcoma; cancerology; Cytologi; onkologi; cancer;

   Sammanfattning : Soft tissue sarcomas (STS) are a heterogeneous group of highly malignant mesenchymal tumors that account for ~1% of all malignancies. Frequent heterogeneity and pleomorphism along with suboptimal diagnostic reproducibility and insufficient prognostic markers make clinical management of these tumors difficult. LÄS MER

3. 2. Neuropeptides and neurotrophins in arthritis : studies on the human and mouse knee joint

   Författare :Ola Grimsholm; Sture Forsgren; Solbritt Rantapää-Dahlqvist; Elvar Theodorsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropeptides; neurotrophins; bombesin gastrin-releasing peptide; substance P; brain-derived neurotrophic factor; synovial tissue; knee joint; rheumatoid arthritis; Anatomy; Anatomi;

   Sammanfattning : Neuropeptides, such as substance P (SP) and bombesin/gastrin-releasing peptide (BN/GRP), and neurotrophins are involved in neuro-immunomodulatory processes and have marked trophic, growth-promoting and inflammation-modulating properties. The impact of these modulators in rheumatoid arthritis (RA) is, however, unclear. LÄS MER

4. 3. Transcriptional patterns in inflammatory disease

   Författare :Johan Lindberg; Joakim Lundeberg; Eivind Hovig; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Gene expression profiling; transcription; microarray; rheumatoid arthritis; synovial tissue; variability; TNF‐α; anti‐TNF treatment; periodontitis; PGE2; Bioengineering; Bioteknik;

   Sammanfattning : In the studies this thesis is based upon, microarrays were applied to profilemRNA populations in biological samples to gain insights into transcriptionalpatterns and their relation to inflammatory disease.Rheumatoid arthritis (RA) is a chronic inflammatory disease, which leads todegradation of cartilage and bone. LÄS MER

5. 4. Metabolism of articular cartilage proteoglycans in vitro : effects of synovial membrane products and mechanical pressure

   Författare :Agneta Klämfeldt; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Articular cartilage; Proteoglycan metabolism; Synovial membrane products; Mechanical stress; Indom ethacin; Glucocorticoids; Prostaglandins; Osteoarthritis; Rheumatoid arthritis;

   Sammanfattning : The effect of synovial membrane products and mechanical pressure upon the metabolism of articular cartilage proteoglycans has been studied in vitro. The degradation of cartilage proteoglycans was studied in an organ culture system and measured as the release of [35S ] sulphate from prelabelled cartilage. LÄS MER

7. 5. Soft Tissue Sarcoma Patterns multiplicity, heterogeneity and growth characteristics

   Författare :Josefin Fernebro; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; Cytologi; oncology; Soft tissue sarcoma; tumor periphery; Medicine human and vertebrates ; Medicin människa och djur ; Cytology; multiple primary tumors; onkologi; cancer;

   Sammanfattning : Soft tissue sarcomas (STS) represent a group of rare and heterogenous tumors that optimally should be diagnosed and treated within multidisciplinary teams. This thesis has studied various aspects ? pathological, genetical, and clinical ? of STS. LÄS MER