Sökning: "synaptotagmin-1"

Hittade 4 avhandlingar innehållade ordet synaptotagmin-1.

  1. 1. Increasing the interpretability of Alzheimer-related biomarkers: cell- and cerebrospinal fluid-based studies with focus on neurogranin

    Författare :Faisal Hayat Nazir; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; biomarker; neurogranin; APP; human iPSCs; CSF;

    Sammanfattning : Biomarkers for Alzheimer’s disease (AD) is a growing field of research. A particularly vibrant field during recent years has been biomarkers for synaptic dysfunction. LÄS MER

  3. 2. The Actin Filament System : Its Involvement in Cell Migration and Neurotransmitter Release

    Författare :Anna-Karin Johnsson; Roger Karlsson; Stéphane Gasman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Actin; Profilin; Synaptotagmin; Cell biology; Cellbiologi; Cell Biology; cellbiologi;

    Sammanfattning : The microfilament system consists of actin filaments as the major component and is regulated by a number of actin binding proteins. It is juxtaposed to the plasma membrane where it forms a dense cortical weave from where it pervades into the cell interior. LÄS MER

  4. 3. Membrane lipids and their transfer proteins in β-cells

    Författare :Beichen Xie; Olof Idevall-Hagren; Anders Tengholm; Jen Liou; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ca2 ; PKC; E-Syt1; TMEM24; ER-PM contact; PI 4; 5 P2; phosphoinositides; β-cell; insulin; optogenetics; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Insulin secretion from β-cells is essential for glucose homeostasis and is often dysregulated in diabetes. Intracellular Ca2+ and membrane lipids cooperate to control insulin secretion with high spatial and temporal precision. LÄS MER

  5. 4. Unraveling pathogenic proteins and pathways in Alzheimer disease : a focus on proteomics

    Författare :Hazal Haytural; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer disease (AD) is a multifactorial and complex neurodegenerative disorder. To date, different mechanisms, such as impairment of synaptic, mitochondrial and autophagic function, neuroinflammation and many more, are found to disrupt cellular homeostasis in AD brains. LÄS MER