Sökning: "sulfasalazine"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet sulfasalazine.

  1. 1. Health economics and its measures in rheumatoid arthritis

    Författare :Johan Karlsson; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cost-utility analysis; Cost-of-illness; Quality of life; EuroQol 5-Dimensions; Antirheumatic agents; TNF inhibition; Outcome assessment; Disease activity; Disability; Health economics; Rheumatoid arthritis;

    Sammanfattning : Objectives: To study: (I) the impact on cost-utility analyses of applying different national EuroQol 5-Dimensions (EQ-5D) preference sets; (II and III) whether, in methotrexate-refractory, early rheumatoid arthritis (RA), the addition of infliximab results in superior health-related quality of life (HRQoL) and may be considered cost-effective, as compared to adding sulfasalazine and hydroxychloroquine; (IV) how costs relate to disability (measured by the health-assessment questionnaire, HAQ), disease activity (28-joint disease activity score, DAS28) and HRQoL (EQ-5D) in RA. Methods: In the observational SSATG register, one-year quality-adjusted life-year (QALY) accumulation of two interventions was compared according to the UK, US, or Danish EQ-5D preference sets. LÄS MER

  3. 2. Endoscopic methods for detecting malignancy in patients with ulcerative colitis and primary sclerosing cholangitis

    Författare :Bo Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ulcerative colitis; primary sclerosing cholangitis; cholangiocarcinoma; colorectal cancer; dysplasia; brush cytology; Endoscopic Retrograde Cholangiopancreatography ERCP .;

    Sammanfattning : Ulcerative colitis (UC) is a chronic ulcerative inflammatory bowel disease affecting the mucosa of the large intestine. UC patients have an increased risk for the development of colorectal cancer mainly associated with long duration and extensive involvement of the colitis. LÄS MER

  4. 3. Constraint-based modeling of metabolism - interpreting predictions of growth and ATP synthesis in human and yeast

    Författare :Avlant Nilsson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; the Crabtree effect; enzyme-constraints; stunting; cellular economy; the Warburg effect; uncoupling; tumor; flux balance analysis; lactate threshold; metabolite depletion;

    Sammanfattning : Growth is the primary objective of the cell. Diseases arise when cells diverge from a healthy growth-pattern. An increased understanding of cellular growth may thus be translated into improved human health. The cell requires materials and free energy (in the form of ATP) in order to grow, metabolism supplies the cell with this. LÄS MER

  5. 4. Chronic inflammation, anti-inflammatory treatment and risk of malignant lymphomas

    Författare :Karin Hellgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of this thesis was to investigate the link between malignant lymphomas and chronic inflammation, in particular the associations between inflammatory activity, immune-modulatory treatment and risk of lymphoma development. To address this aim, we used Swedish population-based registers, mandatory cancer reporting and nation-wide clinical registers including the Swedish Rheumatology Register (SRQ). LÄS MER

  7. 5. Studies on the formation of leukotriene C4 and lipoxins from leukotriene A4 in human platelets

    Författare :Susanne Tornhamre; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human platelets lack 5-lipoxygenase activity, but possess enzymatic capacity to transform the unstable epoxide leukotriene (LT)A4 to the potent inflammatory agent LTC4 and lipoxins, a group of trihydroxylated tetraene-containing eicosanoids, which recently have been suggested to have an anti-inflammatory role. A novel pathway for the formation of lipoxin (LX)A4 via platelet lipoxygenation of SS,6R-diHETE and 5S,6S-diHETE, enzymatic/non-enzymatic hydrolysis products of LTA4, was discovered in human platelets. LÄS MER