Sökning: "subtelomeres"

Hittade 3 avhandlingar innehållade ordet subtelomeres.

1. 1. Genomic and transcripto variation in blood stage Plasmodium falciparum

   Författare :Bobo Mok; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Antigenic variation; comparative genomic hybridization CGH ; copy number polymorphism CNP ; microarray; P. falciparum; PfEMP1; subtelomeric regions; segmental duplication; switching; var;

   Sammanfattning : Malaria research has entered a postgenomic era since October 2002, when the complete genomic sequence of Plasmodium falciparum strain 3D7 was published. A massive amount of information generated by the P. falciparum genome project has facilitated the development of many novel platforms for profiling different levels of biological aspects. LÄS MER

3. 2. Interplay of chromatin remodeling, transcriptional regulation, and nuclear organization

   Författare :Babett Steglich; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Transcription is regulated on different levels to ensure that genes are expressed at the correct time and in the amounts required. At the chromatin level, DNA is wound onto histone proteins, forming nucleosomes that influence accessibility of DNA elements. LÄS MER

4. 3. Trypanosoma cruzi genome plasticity and evolution

   Författare :Carlos Talavera-López; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Trypanosoma cruzi, a protozoan from the Kinetoplastidae family, is the etiologic agent of Chagas disease, a major public health problem affecting mostly the poorest areas of Latin America. Due to the complex nature of the parasite’s genome it has been impossible to produce a complete reference genome sequence, thus hampering the implementation of post- genomic approaches to unveil the mechanisms of generation of antigenic variation and the identification of new drug targets. LÄS MER