Sökning: "steroidogenic enzymes"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden steroidogenic enzymes.

  1. 1. Exploring the steroidogenic activity of glutathione transferases across species

    Författare :Helena Lindström; Bengt Mannervik; Kjell Wikvall; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glutathione transferase; steroidogenesis; GST A3-3; testis; androstenedione; pregnenedione; equine; steroidogenesis inhibition; Drosophila GSTE14; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Glutathione transferases (GSTs) comprise a superfamily of enzymes prominently involved in detoxication. However, some GSTs have developed alternative functions. LÄS MER

  3. 2. Steroids and steroid-metabolizing enzymes in the nervous system : Special focus on cell survival and sex hormone synthesis

    Författare :Ida Emanuelsson; Maria Norlin; Kjell Wikvall; Lena Ekström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biokemi; Biochemistry;

    Sammanfattning : Some steroids in the brain and peripheral nervous system have been shown to have neuroprotective effects but the knowledge is limited. The present study examines the effects of steroids including oxysterols, vitamin D and vitamin D analogs on cell viability/growth and steroidogenesis in the nervous system. LÄS MER

  4. 3. Transcriptional regulation by the nuclear receptors steroidogenic factor-1 and liver receptor homologue-1

    Författare :Anna Ehrlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Steroidogenic Factor-1 (SF-1) and Liver Receptor Homologue-1 (LRH-1) are transcription factors belonging to the nuclear receptor (NR) family. In the adrenal cortex and gonads, SF-1 governs the expression of multiple enzymes and transporters required for converting cholesterol to steroid hormones. LÄS MER

  5. 4. Expression and regulation of steroid metabolizing enzymes in cells of the nervous and skeletal systems : Special focus on vitamin D metabolism

    Författare :Mokhtar Almokhtar; Maria Norlin; Kjell Wikvall; Gösta Eggertsen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Little is known about the mechanisms of vitamin D actions in the brain and bone. In this study, the metabolism of vitamin D and its regulation in various cell cultures of the nervous and skeletal systems were examined. LÄS MER

  7. 5. Effects of endocrine disruptors on adreno-cortical and Leydig cell steroidogenesis

    Författare :Vichit Supornsilchai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endocrine disrupting chemicals EDCs ; steroidogenesis; Leydig cells; adrenocortical cells; steroidogenic acute regulatory protein StAR ; steroidogenic enzymes;

    Sammanfattning : A common sequential pathway for steroidogenesis, designed to produce steroid hormones, is expressed in the adrenal cortex, testes and ovaries. In this process, cholesterol is converted to all known steroids by specific enzymes in a tissue-specific manner. LÄS MER