Sökning: "salicylidene acylhydrazide"

Hittade 3 avhandlingar innehållade orden salicylidene acylhydrazide.

  1. 1. Small Molecules as Tools in Biological Chemistry : Effects of Synthetic and Natural Products on the Type III Secretion System

    Författare :Caroline E. Zetterström; Mikael Elofsson; Samuel I. Miller; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Type III secretion; salicylidene acylhydrazide; virulence-blocker; virulence; inhibitor; target identification; neohopeaphenol A; Yersinia pseudotuberculosis; Pseudomonas aeruginosa; Escherichia coli; biologisk kemi; biological chemistry;

    Sammanfattning : The increasing use of antibiotics has led to a huge problem for society, as some bacteria have developed resistance towards many of the antibiotics currently available. To help find solutions to this problem we studied small molecules that inhibit bacterial virulence, the ability to cause disease. LÄS MER

  3. 2. Antivirulent and antibiofilm salicylidene acylhydrazide complexes in solution and at interfaces

    Författare :Shoghik Hakobyan; Madeleine Ramstedt; Jean-Francois Boily; Mikael Elofsson; Marcus Textor; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antivirulent; Antibiofilm; Hydrazones; Gallium; Pseudomonas aeruginosa; Type three secretion system; Equilibrium constant; Chemical equilibrium modelling; Spectrophotometric titration; UV-Vis;

    Sammanfattning : The growing bacterial resistance against antibiotics creates a limitation for using traditional antibiotics and requests development of new approaches for treatment of bacterial infections. Among the bacterial infections that are most difficult to treat, biofilm-associated infections are one of the most hazardous. LÄS MER

  4. 3. Caenorhabditis elegans as a model to elucidate host-pathogen interactions for human bacterial pathogens

    Författare :Xiao Hui Sem; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The soil nematode Caenorhabditis elegans is a popular host utilized to model bacterial virulence and microbial pathogenesis in vivo. This thesis explores the use of C. elegans for the study of host-pathogen interactions for two Gram-negative bacteria, Burkholderia thailandensis and Salmonella enterica. LÄS MER