Sökning: "rnRNA"

Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet rnRNA.

  1. 1. Estrogen receptor gene activity within the brain and the relation to psychiatric disorders : mapping and function

    Författare :Marie Österlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :steroid hormone; ER system; in situ hybridization; rnRNA; ER serotonin; depression; affective disorders;

    Sammanfattning : Estrogens have for a long time been known to regulate neuroendocrine functions in the central nervous system (CNS), primarily related to reproduction. In recent years estrogens have been found to also modulate many other brain functions, for example mood and cognition. LÄS MER

  3. 2. Regulation of prostaglandin E2 synthesis in human gingival fibroblasts

    Författare :Tülay Yucel-Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :prostaglandin E2; cyclooxygenase; phospholipase A2 interleukin-1; tumor necrosis factor [alpha]; epidermal growth factor; protein kinase C; tyrosine kinases; human gingival fibroblasts;

    Sammanfattning : Prostaglandins, especially, prostaglandin E2 (PGE2) play an important role in inflammatory diseases such as rheumatoid arthritis and periodontitis. The aim of the present thesis was to study the production and the regulation of PGE2 with special reference to the key enzymes phospholipase A2 (PLA2) and cyclooxygenase (COX) at the rnRNA level in human gingival fibroblasts. LÄS MER

  4. 3. Thyroid hormone receptor expression in cardiovascular disease and pharmacology

    Författare :Shiva Shahrara; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :TR mRNA; amiodarone; propranolol; heart rate; Quantitative RT-PCR; Western blot; Northern blot; mRNA and protein distribution; chronic valvular disease; Mated cardiomyopathy; AT- I cardiomyocytes; mouse myocardium;

    Sammanfattning : The heart is a major target organ for thyroid hormone actions. Thyroid hormone exerts effects on the myocardium, which are mediated by specific nuclear receptors. The thyroid hormone receptors (TR) are members of the steroid hormone receptor superfamily. LÄS MER

  5. 4. Steroid converting enzymes in breast cancer

    Författare :Cecilia Gunnarsson; Tommy Fornander; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Estrogens play a central role in the development of breast cancer. Most breast carcinomas are detected after menopause and despite a low degree of ovarian estrogen production and low levels of serum estrogen these tumors show a high in situ level of estrogens. LÄS MER

  7. 5. Telomerase activity and its regulation in malignant hematopoietic cells

    Författare :Dawei Xu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hTERT mortalization malignancy activity telomerase regulation;

    Sammanfattning : Telomerase, a multicomponent ribonucleoprotein, synthesizes TTAGGG telomeric repeats essential for the stability and integrity of chromosomes. Most normal human somatic cells exhibit undetectable telomerase activity. LÄS MER