Sökning: "reuptake inhibitor"

Visar resultat 1 - 5 av 44 avhandlingar innehållade orden reuptake inhibitor.

1. 1. On the efficacy and prescription of serotonin reuptake inhibitors

   Författare :Alexander Lisinski; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antidepressants; antidepressive agents; major depressive disorder; selective serotonin reuptake inhibitor; serotonin and noradrenaline reuptake inhibitor; tricyclic antidepressant;

   Sammanfattning : This thesis addresses several controversial issues regarding commonly used antidepressants, including selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs). To this end, patient-level data from 28 placebo-controlled trials on SSRIs and 13 corresponding trials on the SNRI duloxetine, were requested and obtained. LÄS MER

3. 2. On the Effects of Serotonin Reuptake Inhibitors in Major Depression

   Författare :Fredrik Hieronymus; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antidepressants; antidepressive agents; depression; major depressive disorder; selective serotonin reuptake inhibitor; SNRI; SSRI;

   Sammanfattning : This thesis focuses on the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) and how these are reflected by the Hamilton Depression Rating Scale (HDRS). To this end, we have assembled a large data set of placebo-controlled SSRI trials in major depression, and used this for a series of post-hoc patient-level analyses. LÄS MER

4. 3. On the biology of premenstrual dysphoria and panic disorder

   Författare :Hoi-Por Ho; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serotonin; reuptake inhibitor; estrogen; progesterone; irritability; respiration; estrus cycle; polymorphism; resident intruder model;

   Sammanfattning : Premenstrual dysphoria (PMD) afflicts 7% of all women of fertile age, and is characterized by symptoms such as irritability, sadness, and mood swings, appearing regularly before menstruation, and being of such severity that they markedly reduce quality of life. The symptoms are dependent of sex steroids, and seem to be under the influence of serotonin, since they respond to treatment with serotonin reuptake inhibitors (SRIs). LÄS MER

5. 4. On the hypersensitivity syndrome induced by the selective serotonin reuptake inhibiting antidepressant Zimeldine : A clinical and experimental study

   Författare :Bengt-O Bengtsson; Linköpings universitet; []
   Nyckelord :Zimeldine; Norzimeldine; Hypersensitivity syndrome; Serotonin reuptake inhibition; Genetic disposition; Lymphocyte transformation test; Experimental allergic neuritis; Immunopharmacology; MEDICINE; MEDICIN;

   Sammanfattning : Zimeldine, the first selective neuronal serotonin (5-H1) reuptake inhibitor to be registered as an antidepressant was withdrawn from common use due to an acute flu-like adverse syndrome comprising fever, myalgia and/or arthralgia and signs of disturbed liver function. A few of these patients also developed a peripheral neuropathy, in the most serious form a Guillain-Barré syndrome (GBS). LÄS MER

7. 5. Posttraumatic Stress Disorder (PTSD) in the General Population

   Författare :Örjan Frans; Mats Fredrikson; Hans Ågren; Uppsala universitet; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Psychology; posttraumatic stress disorder; trauma; epidemiology; general population; prevalence; traffic road accidents; DSM-structure; positron emission tomography; regional cerebral blood flow; symptom provocation; selective serotonin reuptake inhibitor; Psykologi; Psychology; Psykologi; klinisk psykologi; Clinical Psychology;

   Sammanfattning : This thesis explored the epidemiology of Posttraumatic Stress Disorder (PTSD) and different aspects of the disorder. Firstly, we investigated the lifetime prevalence of traumatic experiences and PTSD in the general adult population in Sweden and evaluated the impact of different trauma types, trauma frequency, and perceived distress. LÄS MER