Sökning: "recombinant antibodies"

Visar resultat 1 - 5 av 198 avhandlingar innehållade orden recombinant antibodies.

  1. 1. Recombinant Antibodies – Tools for building proteomic platforms

    Författare :Anna Säll; Institutionen för immunteknologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibody development; recombinant scFv antibodies; phage display; affinity proteomics; mass spectrometry;

    Sammanfattning : This thesis, which is based on four original papers, covers different aspects of the evolvement and development of proteomic platforms and the construction of human synthetic antibody libraries for the isolation of antibody reagents has been very central. There is an accelerating need for technologies capable of providing proteomic analysis of high sensitivity with good accuracy and an overall broad coverage as well as for biomarker validation. LÄS MER

  3. 2. Recombinant antibodies and tumor targeting

    Författare :Ali Sheikholvaezin; Torgny Stigbrand; Gregory P Adams; Umeå universitet; []
    Nyckelord :immunologi; Immunology;

    Sammanfattning : Different antibody derived constructs are rapidly advancing as putative tools for treatment of malignant diseases. Antibody engineering has added significant new technologies to modify size, affinities, solubility, stability and biodistribution properties for immunoconjugates. LÄS MER

  4. 3. Immunological characteristics of recombinant fragments of the Plasmodium falciparum blood-stage antigen Pf332

    Författare :Halima A. Balogun; Klavs Berzins; Lars Hviid; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Plasmodium falciparum; Pf332; antibodies; immunity; growth inhibition; Immunology; Immunologi; immunologi; Immunology;

    Sammanfattning : Effective malaria vaccine might help improve control strategies against malaria, but the complexity of interactions between the parasite and its hosts poses challenges. The asexual blood stage P. falciparum antigen Pf332 has potentials as one of the proteins in understanding the complex host-parasite interactions. LÄS MER

  5. 4. Validation of antibodies for protein profiling : A study using immunohistochemistry on tissue microarrays

    Författare :Linda Paavilainen; Fredrik Pontén; Ola Nilsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody validation; monospecific antibodies; protein profiling; immunohistochemistry; tissue microarrays; western blot; fixatives; Pathology; Patologi; Pathology; patologi;

    Sammanfattning : The field of proteomics has rapidly expanded due to the completion of the human genome sequence. This thesis validates affinity-purified monospecific antibodies of polyclonal origin, for protein profiling in a broad spectrum of normal tissues and cells. LÄS MER

  7. 5. Immunoglobulins, immunoglobulin subclass-distributions and serologic markers in some renal and systemic disorders

    Författare :Gabriel Almroth; Jan Björklander; Linköpings universitet; []
    Nyckelord :Immunoglobulins; immunoglobulin-subclass distribution; hydralazine; ANCA; anti-:MPO; primary SjOgren s syndrome; hepatitis B vaccination; anti-HBssubclasses; immunoadsorption; plasmapheresis; antibodies; hepatitis C virus; transmission; recombinant immunoblot assay; hepatitis C genotype; MEDICINE; MEDICIN;

    Sammanfattning : In this study we evaluated pathogenetic factors and possible mediators of renal and systemic disorders where immunologic mechanisms might be of importance.An abberant immunoglobulin and IgG-subclass distribution was detected in 103 patients with primary and secondary glomerulonephritis as well as in 38 patients with the systemic disease primary Sjögren 's syndrome or purpura hypergammaglobulinemica (elevated IgG1 and low IgG2 ). LÄS MER