Sökning: "receptor dimerization"

Visar resultat 1 - 5 av 26 avhandlingar innehållade orden receptor dimerization.

  1. 1. New Paradigms in GPCR Drug Discovery : Structure Prediction and Design of Ligands with Tailored Properties

    Författare :Mariama Jaiteh; Jens Carlsson; David E Gloriam; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G Protein-Coupled Receptor; Molecular Docking; Virtual Screening; Homology Modeling; Molecular Dynamics Simulation; Chemical Library; Functionally Selective Ligand; Polypharmacology; Dimerization; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. LÄS MER

  3. 2. Structure and function of the HDL receptor SR-BI : scavenger receptor class B type I

    Författare :Magnus S.C. Johnson; Göteborgs universitet; []
    Nyckelord :SR-BI; HDL; Cholesterol; Scavenger receptor; Apoptosis; Ovary; Gallbladder; Peroxisome;

    Sammanfattning : Low plasma levels of high-density lipoprotein (HDL) and high levels of low-density lipoprotein (LDL) are well-recognized risk factors for cardiovascular disease. The uptake and degradation of LDL cholesterol have been characterized in detail at the molecular level. Less is known about the metabolism and cellular uptake of HDL cholesterol. LÄS MER

  4. 3. Receptors for growth hormone and prolactin. Regulation and activation

    Författare :Gunnel Hellgren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; GH receptor; Janus kinase; GH sensitivity; 5 -untranslated region; prolactin; prolactin receptor adipose tissue; liver; skeletal muscle; epidermal growth factor receptor; tyrosine kinase; kinase activity;

    Sammanfattning : Cytokine receptor activation is dependent on ligand-induced receptor dimerization or oligomerization and subsequent activation of several intracellular proteins. Activation of Janus kinases (Jaks) is probably the first intracellular event that occurs after receptor dimerization. LÄS MER

  5. 4. EGFR- and HER2-Binding Affibody Molecules : Cellular studies of monomeric, dimeric and bispecific ligands

    Författare :Lina Ekerljung; Lars Gedda; Johan Lennartsson; Jörgen Carlsson; Birgitta Sundström; Uppsala universitet; []
    Nyckelord :EGFR; HER2; Affibody molecule; cell signaling; receptor dimerization; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Abnormal expression and signaling of the ErbB receptors is associated with the development and progression of several forms of cancer. In this thesis, new ErbB-targeting affibody molecules are evaluated regarding their cellular effects in vitro. LÄS MER

  7. 5. Design and engineering of human transferrin receptor 1 and its binding proteins

    Författare :Dick J. Sjöström; Sinisa Bjelic; John Löfblom; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Transferrin receptor; Machupo virus; protein engineering; Rosetta; flow cytometry; directed evolution; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : The human transferrin receptor 1 (TfR) is central in maintaining adequate cellular iron levels with the iron carrier proteins transferrin (Tf) and ferritin (Ft). Known to bind TfR is also HFE, another iron regulatory protein, competing with Tf for receptor binding. LÄS MER