Sökning: "re-targeting"
Hittade 3 avhandlingar innehållade ordet re-targeting.
1. Genetic re-targeting and de-targeting of adenovirus type 5 in order to create vectors for gene therapy
Sammanfattning : Gene therapy has been considered to be a revolutionary development in medicine, whereby the cause and not the symptoms of the disease would be treated. These expectations have as yet not been realized, mainly due to lack of suitable vectors. LÄS MER
2. Genetic re-targeting of adenoviral vectors for gene therapy applications
Sammanfattning : The adenovirus (Ad) is a frequent cause of upper respiratory tract infections, enteritis and conjunctivitis. Since its first isolation in 1953, the study of Ad has contributed greatly to the understanding of intracellular events and has also served as a model system for many viruses. LÄS MER
3. Targeting molecular mechanisms for epigenetic silencing in multiple myeloma : Implications for biology and precision medicine
Sammanfattning : Multiple myeloma (MM) is a heterogeneous haematological cancer where malignant plasma cells clonally expand within the bone marrow. The transcriptional repressor PRC2 and its catalytic subunit EZH2 play a major role in MM, as PRC2 re-targeting results in a MM-specific gene silencing profile. LÄS MER