Sökning: "rat strains"

Visar resultat 21 - 25 av 101 avhandlingar innehållade orden rat strains.

  1. 21. Molecular basis for the MHC class II association in rat experimental autoimmune encephalomyelitis

    Författare :Katrien L de Graaf; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis investigates the functional and structural aspects of rat MHC class 11 molecules and studies their influence on MBP- and MOG-peptide induced experimental autoimmune encephalomylitis (EAE) in LEW MHC congenic rat strains. EAE is an animal model for multiple sclerosis (MS) and can be induced in rats with components of the myelin sheath . LÄS MER

  3. 22. Identification of genes that regulate arthritis and IgE production in rat and human

    Författare :Ulrica Ribbhammar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :RA; experimental animal model; QTL; congenic strain; APLEC; asthma; total IgE;

    Sammanfattning : Multiple genome-wide scans have identified quantitative trait loci (QTLs) that influence inflammatory diseases on chromosome 4q42 in DA rats. Several of the QTLs overlap with the QTL designated Oia2 (Oil-induced arthritis-2), which was originally identified in a genomewide linkage analysis in oil-induced arthritis (OIA), a model that shows similarities to rheumatoid arthritis (RA) in human. LÄS MER

  4. 23. Identification and characterization of candidate genes for type 2 diabetes in the GK rat

    Författare :Hossein Fakhrai-Rad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Type 2 diabetes is a common multifactorial disorder with complex genetics, which presents with a heterogeneous clinical phenotype as a result of interaction between genetic susceptibility and environmental risk factors. Hence, the search for susceptibility genes for type 2 diabetes in man is difficult. LÄS MER

  5. 24. Studies on Oral Immune Reactions in the Genetically Mercury-Sensitive BN Rat and in the Hyperplastic BN-(BNxLEW) Graft-versus-Host Disease

    Författare :Michael J Peszkowski; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T-lymphocytes; Immunohistochemistry; autoimmunity; stomatology; Odontology; Odontologi;

    Sammanfattning : Mercury (Hg) is known to induce adverse immune reactions in sensitive individuals. e.g. selected inbred animal strains. LÄS MER

  7. 25. Genetic differences in neuropathy and opioid responses in rats

    Författare :Aleksandra Bulka; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Allodynia; genetic difference; neuropathic pain; NMDA-receptor; opioids; rat strains; pharmacokinetics; tolerance.;

    Sammanfattning : The studies examined mechanisms and treatments of experimental neuropathic pain with particular emphasis on the differences between rat strains and sub-strains in basal nociceptive sensitivity, development of neuropathic behaviors and sensitivity to opioid analgesia. In order to study the mechanisms that mediate mechanical allodynia (touch-evoked pain) following ischemic nerve injury to the sciatic nerve in rats, the myelinated primary afferents have been examined in the injured and intact nerves. LÄS MER