Sökning: "rat strains"

Visar resultat 11 - 15 av 101 avhandlingar innehållade orden rat strains.

  1. 11. Immunologic and genetic studies of rat adjuvant-induced arthritis

    Författare :Åsa Jansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :arthritis; autoimmunity; adjuvant; incomplete Freund s adjuvant; squalene; quantitative trait locus;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with a multifactorial and largely unknown etiology. It is influenced by both environmental and genetic factors, and understanding of disease mechanisms and identification of disease-causing genes is hampered by the complex and polygenic nature of the disease. LÄS MER

  3. 12. Mechanisms of opiate tolerance and dependence in the rat

    Författare :Orsolya Hoffman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Drug addiction is a complex phenomenon with various biological, psychological and social causes and consequences, which belongs to the major problems of today's society. Opiates have been used and misused for thousand of years and addiction to them develops both in humans and in animals. LÄS MER

  4. 13. Plasticity in mice nociceptive spinal circuits -role of cell adhesion molecules

    Författare :Jonas Thelin; Neurofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Long term-potentiation; Cell adhesion molecule; Pain; Somatosensory imprinting; Medicin människa och djur ; Medicine human and vertebrates ; Nociceptive withdrawal reflex; Species differences; Central sensitisation; Mouse strains; Spinal cord;

    Sammanfattning : Introduction: To understand the function of the genes and their products in the pain system, studies will have to deal with complex issues related to intercellular communication, e.g. plasticity in neuronal networks. LÄS MER

  5. 14. Novel Tumor Suppressor Gene Candidates in Experimental Endometrial Carcinoma - From Cytogenetic to Molecular Analysis

    Författare :Carola Hedberg; Göteborgs universitet; []
    Nyckelord :cancer; endometrial cancer; tumor suppressor gene; rat models; Skip; Myo1c;

    Sammanfattning : Endometrial carcinoma (EC) is the most common form of gynecological malignancy, ranking fourth in incidence among tumors diagnosed in women. As is the case with other complex diseases, detailed analyses of the underlying mechanisms of cancer are difficult, due mainly to the genetic heterogeneity of the human population and differences in the environment and lifestyle of individuals. LÄS MER

  7. 15. Type 2 Diabetes Genes Contributing to Insulin Secretion Defects

    Författare :Charlotte Granhall; Genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sekretion; Endokrinologi; exocytosis; GK rat; NIDDM1I; genetics; gene expression; quantitative trait analysis; Sorcs1; Adra2a; Endocrinology; diabetology; insulin secretion; diabetologi; secreting systems; Type 2 diabetes;

    Sammanfattning : Type 2 diabetes is caused by a combination of environmental and inherited factors influencing the progression of insulin resistance and impaired insulin secretion leading to chronically elevated blood glucose levels. The aim of this thesis was to functionally and genetically characterise the species-conserved diabetes locus Niddm1i of the GK rat encoding hyperglycaemia and defect insulin secretion. LÄS MER