Sökning: "quinolinic acid"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden quinolinic acid.
1. Tryptophan-related Neurotransmission in the Brain: Disturbances Associated with Experimental Hepatic Encephalopathy
Sammanfattning : In the present study, L-tryptophan (TRP)-related disturbances in the brain in experimental hepatic encephalopathy (HE) were investigated. The endogenous NMDA-receptor agonist and L-TRP metabolite quinolinic acid (QUIN) has been suggested to be involved in the pathogenesis of HE. LÄS MER
2. Dysregulation of the kynurenine pathway in psychotic disorders : immunological aspects
Sammanfattning : Kynurenic acid (KYNA), a metabolite of the kynurenine pathway, is emerging as a key factor in the development of psychotic disorders. Increased levels of KYNA are found in the brain and cerebrospinal fluid (CSF) of patients with schizophrenia and bipolar disorder, and are associated to psychotic symptoms. LÄS MER
3. The kynurenine pathway in body and brain : relation with physical exercise and mental health
Sammanfattning : The kynurenine pathway of tryptophan degradation is the focus in a variety of research fields and several of the metabolites produced along the pathway are suggested as future biomarkers. Growing interest in a better understanding of the physiological and the pathophysiological importance of kynurenine pathway metabolites is followed by the need for a robust, sensitive method that can quantify multiple metabolites simultaneously. LÄS MER
4. Immunological and Inflammtory Responses against Intrastriatal Neural Grafts in the Rat
Sammanfattning : Intracerebral neural transplantation offers a new strategy to combat Parkinson’s and Huntington’s diseases. However, a host immune response against a histoincompatible neural graft in the brain may jeopardize transplant survival. LÄS MER
5. Effects of dopamine and excitotoxicity in experimental models of Huntington's disease
Sammanfattning : Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expansion of a CAG repeat in the HD gene, that leads to dysfunction and death of striatal neurons. The pathogenetic mechanisms underlying HD are not known, but excitotoxicity and dopamine (DA) have been suggested to play a role. LÄS MER