Sökning: "pyroptosis"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet pyroptosis.

  1. 1. Timing Matters : Wounding and entomopathogenic nematode infection kinetics

    Författare :Alexis Dziedziech; Ulrich Theopold; Angela Giangrande; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drosophila melanogaster; Heterorhabditis bacteriophora; Photorhabdus luminescens; entomopathogenic nematodes; worms; high-resolution microscopy; time-lapse; infection; kinetics; sepsis; septic wounding; injury; clotting; glutactin; transglutaminase; prophenoloxidase; cell death; pyroptosis; caspase; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Over time, insects have developed complex strategies to defend themselves against presenting threats. However, in the evolutionary arms race of survival, pathogens have adapted to quickly overcome the immune response mounted by the host. LÄS MER

  3. 2. Inflammatory cell death of human macrophages induced by Aggregatibacter actinomycetemcomitans leukotoxin

    Författare :Peyman Kelk; Anders Johansson; Charels A Dinarello; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aggregatibacter actinomycetemcomitans; leukotoxin; IL-1β; caspase-1; inflammatory cell death; pyroptosis; ODONTOLOGY; ODONTOLOGI; odontologi; Odontology;

    Sammanfattning : Aggregatibacter (Actinobacillus) actinomycetemcomitans is a bacterium mainly associated with aggressive forms of periodontitis. Among its virulence factors, a leukotoxin is suggested to play an important role in the pathogenicity. LÄS MER

  4. 3. Characterization of the attenuated Francisella tularensis strain FSC043 : with special focus on the gene pdpC

    Författare :Marie Lindgren; Anders Sjöstedt; Marina Santic; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; intracellular bacteria; J774; apoptosis; pyroptosis; PdpC; FSC043; Clinical Bacteriology; klinisk bakteriologi; mikrobiologi; Microbiology;

    Sammanfattning : Francisella tularensis is a highly infective, intracellular bacterium. It is capable of infecting a wide range of mammals and causes the disease tularemia in humans. As a result of its high infectivity there have been a lot of efforts made to create a generally available vaccine against this pathogen. LÄS MER

  5. 4. Roles in innate immune receptors : host – pathogen interactions and strengthening vaccines

    Författare :Sanna Nyström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During the past decades our knowledge of innate immunology has increased drastically. This has improved our understanding about how innate immune cells can distinguish self from non-self, commensal bacteria from pathogens, and how it affects later adaptive immune responses. LÄS MER

  7. 5. Regulation of inflammasomes by host- and pathogen-derived factors

    Författare :Dora Hancz; Värd-patogeninteraktioner; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Innate Immunity; pattern recognition receptors; inflammasome; Streptococcus pyogenes;

    Sammanfattning : The term inflammasome was first coined in 2002 and describes an intracellular multiprotein complex mediating inflammation by inducing the release of pro-inflammatory cytokines (IL-1β and IL-18) and a lytic form of cell death called pyroptosis. Since then, an impressive amount of research has revealed many details about the mechanisms of inflammasome activation as well as the functional relevance of inflammasome activation in different contexts. LÄS MER