Sökning: "purinoceptors"

Hittade 5 avhandlingar innehållade ordet purinoceptors.

1. 1. Studies of nucleotide receptors-induced calcium response in glomerular mesangial cells and afferent arterioles

   Författare :Antonio M. Gutiérrez; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; mesangial cells; nucleotide receptors; purinoceptors; desensitization; afferent arterioles; ATP; UTP; adenosine; protein phosphatases; calcium; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

   Sammanfattning : It is known that intracellular calcium concentration ([Ca2+]i) changes in rat glomerular mesangial cells (GMC) and rabbit afferent arterioles (AA) in response to extracellular nucleotides. We studied the nucleotide-induced calcium response in cultured GMC and AA. LÄS MER

3. 2. On the autonomic control of the lower urinary tract. Functional and morphological aspects in the normal and the inflamed urinary bladder

   Författare :Daniel Giglio; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muscarinic receptor; purinoceptor; adrenoceptor; nitric oxide; in vitro; in vivo; cystometry; Western blot; immunohistochemistry; cystitis; cyclophosphamide; urinary bladder; rat;

   Sammanfattning : The regulation of urinary bladder function involves interplay of signalling systems. Disturbances in any of the interactive systems may result in lower tract dysfunction, which is often apparent to the patient by urge to void or by incontinence, irrespectively of the cause to the lower tract syndrome. LÄS MER

4. 3. Function of contractile and cytoskeletal proteins in smooth muscle: Effects of hypertrophy and age and desmin removal in a transgenic animal

   Författare :Rolf Sjuve; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transgenic mouse; desmin; embryonic myosin; isoforms; myosin heavy chain; age; smooth muscle; hypertrophy; Physiology; Fysiologi;

   Sammanfattning : In man, the urinary bladder responds to an urinary outflow obstruction with a pronounced dilatation and growth of the bladder wall. This clinical situation can be mimicked in rat by creation of a partial urinary outflow obstruction and the papers included in the present thesis use this animal model to address questions regarding the adaptive changes in the smooth muscle of the growing bladder. LÄS MER

5. 4. Functional studies of purinergic and cholinergic interactions in the rat urinary bladder - Characterization of ATP-evoked urothelial release of acetylcholine

   Författare :Johanna Stenqvist; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP; acetylcholine; urothelium; caveolae; afferents; cystitis;

   Sammanfattning : Functional interplays between different transmitter systems are known to affect the signalling of the micturition reflex arc. The functional implications of many of these interactions, such as between ATP and acetylcholine, have yet to be unravelled. LÄS MER

7. 5. Cell signalling in cancer. A functional and immunochemical investigation of purinergic,adrenergic, nitrergic, and prostaglandin mediated signalling mechanisms in experimental and human cancer

   Författare :Gunnar Nylund; Göteborgs universitet; []
   Nyckelord :adenosine-5´-triphosphate; colon cancer; extracellular acidification; melanoma; ; microphysiometer; nitric oxide; noradrenaline; prostaglandin E2; sarcoma; tumour cell; metabolism; uridine-5´-triphosphate;

   Sammanfattning : Disturbed cell signalling is a hallmark of the cancer cell, being one important mechanismbehind uncontrolled cell growth. In the current study, we have investigated cancer cellsignalling with the focus on some first messenger and/or their receptors, in the murine celllines, MCG 101, and K1735-M2, and the human colon cancer cell line, HT-29. LÄS MER