Sökning: "psoralen"

Hittade 2 avhandlingar innehållade ordet psoralen.

1. 1. Interstrand Crosslinks - Induction and repair

   Författare :Daniel Vare; Dag Jenssen; Klaus Erixon; Fredrik Johansson; Marcel Tijsterman; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ICL; DNA repair; interstrand crosslink; psoralen; molekylärgenetik; Molecular Genetics;

   Sammanfattning : DNA crosslinking agents exhibit a variety of DNA lesions, such as monoadducts, DNA-DNA interstrand or intrastrand crosslinks or DNA-protein crosslinks. Agents that produce interstrand crosslinks (ICLs) exist naturally and are widely used in chemotherapy. Therefore, it is important to understand how the lesions induced by these agents are repaired. LÄS MER

3. 2. Long-wave ultraviolet radiation (UVA1) and visible light : therapeutic and adverse effects in human skin

   Författare :Desiree Wiegleb Edström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ultraviolet-A; visible light; p53; p21WAF-1; bcl-2; CD34; port-wine stains; mycosis fungoides; dye laser; photodynamic therapy.;

   Sammanfattning : We studied the effects of repetitive low-dose UVA1 radiation and visible light in normal sunshielded skin, using immunohistochemical staining for p53, p21WAF-1, bcl-2, Ki67 and cyclin A. An increased expression of Ki67 after UVA1 and visible light were observed as a sign of increased proliferation. LÄS MER