Sökning: "protein kinase A"

Visar resultat 1 - 5 av 910 avhandlingar innehållade orden protein kinase A.

1. 1. The choreography of protein vibrations : Improved methods of observing and simulating the infrared absorption of proteins

   Författare :Eeva-Liisa Karjalainen; Andreas Barth; Astrid Gräslund; Timothy A. Keiderling; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Infrared spectroscopy; FTIR; protein; atpase; amyloid; caged compound; amide I; transition dipole coupling; exciton theory; simulation; Molecular biophysics; Molekylär biofysik; Biophysics; biofysik;

   Sammanfattning : The work presented in this thesis has striven toward improving the capability to study proteins using infrared (IR) spectroscopy. This includes development of new and improved experimental and theoretical methods to selectively observe and simulate protein vibrations. LÄS MER

3. 2. The Adenovirus L4-33K Protein : A Key Regulator of Virus-specific Alternative Splicing

   Författare :Heidi Törmänen Persson; Göran Akusjärvi; Stefan Schwartz; Marie Öhman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; L4-33K; adenovirus; splicing; phosphorylation; localization; replication centers; L4-22K; MLTU; DNA-PK; DNA-dependent protein kinase; PKA; cAMP-dependent protein kinase; transcription sites; SR protein; Medical Virology; Medicinsk virologi;

   Sammanfattning : Adenoviruses have been extensively studied in the field of gene regulation, since their genes are subjected to a tightly controlled temporal expression during the virus lifetime. The early-to-late shift in adenoviral gene expression distinguishes two completely different programs in gene expression. LÄS MER

4. 3. Revealing Secrets of Synaptic Protein Interactions : A Biosensor based Strategy

   Författare :Christian Seeger; U Helena Danielson; Sarah Lummis; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surface plasmon resonance; biosensor; AMPA receptor; GABAA receptor; ligand-gated ion channel; A-kinase anchoring protein; caldendrin; calmodulin; HIV; fragment based drug discovery; Biokemi; Biochemistry; Neuroscience; Neurovetenskap;

   Sammanfattning : Protein interactions are the basis of synaptic function, and studying these interactions on a molecular level is crucial for understanding basic brain function, as well as mechanisms underlying neurological disorders. In this thesis, kinetic and mechanistic characterization of synaptic protein interactions was performed by using surface plasmon resonance biosensor technology. LÄS MER

5. 4. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells

   Författare :Jon A Tsai; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :hOB cells; PTHrP; cAMP; IGFs; IGFBPs; IL-1ß; TGF-ß; [Ca 2 ]i; [Ca2 ]O;

   Sammanfattning : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. LÄS MER

7. 5. Myosin 1c taking adrenergic metabolism for a spin : More than a motor protein

   Författare :Alice Åslund; Tore Bengtsson; Michael Czech; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glucose uptake; Glucose transporter; Brown adipose tissue; White adipose tissue; Skeletal muscle; Myosin1c; Nuclear myosin I; Physiology; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Metabolic diseases like type II diabetes (T2D) and obesity largely stems from an unbalanced energy homeostasis with the fails of the insulin pathway to the point in which the glucose homeostasis is severely disturbed leading to hyperglycemia. We have investigated if the β-adrenergic signaling pathways, in both brown adipose tissue (BAT) and skeletal muscle, could be used as a strategy to alleviate metabolic disease. LÄS MER