Sökning: "protein disulfide isomerase"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden protein disulfide isomerase.

  1. 1. Protein disulfide isomerase : function and mechanism in oxidative protein folding

    Författare :Ruoyu Xiao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Protein disulfide isomerase; endoplasmic reticulum; protein folding;

    Sammanfattning : The formation of native intramolecular disulfide bonds is critical for the folding and stability of many secreted proteins. This process involves oxidation of protein thiols to form disulfide bonds as well as rearrangement of any non-native disulfide bonds that might form. LÄS MER

  3. 2. Studies on Redox-proteins and Cytokines in inflammation and Cancer

    Författare :Akter Hossain; Anders Rosén; Christer Lindqvist; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thioredoxin Trx ; Selenium; Tumor necrosis factor TNF ; Cancer; nflammation; oxidative stress; Protein-disulfide isomerase PDI ; Tumor necrosis factor receptor TNFR ; Medical cell biology; Medicinsk cellbiologi;

    Sammanfattning : The redox state in the cell plays a major role in determining vital functions and its major imbalance can lead to severe cell injury or death. Redox active proteins and cytokines involved in this process includes thioredoxin (Trx), protein disulfide isomerase (PDI), and tumor necrosis factor (TNF) superfamilies. LÄS MER

  4. 3. Crystallographic studies on redox enzymes containing the thioredoxin fold

    Författare :Bin Ren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Three-dimensional structure; the thioredoxin fold; glutathione peroxidase; protein disulfide oxidoreductase; protein crystallography;

    Sammanfattning : Three-dimensional structures of two redox enzymes, glutathione peroxidase from human plasma and a protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus, have been determined by X-ray crystallography. Glutathione peroxidases constitute a family of antioxidant seleno-enzymes that catalyze the reduction of a variety of hydroperoxides. LÄS MER

  5. 4. The assembly and secretion of ApoB containing lipoproteins

    Författare :Pia Stillemark; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apolipoprotein B; lipoprotein; VLDL; microsomal triglyceride transfer protein; chaperone;

    Sammanfattning : Increased levels of cholesterol and triglycerides in the blood are important risk factors for the development of premature atherosclerosis and its complications such as coronary-heart diseases, stroke and peripheral vascular diseases. These diseases are the major causes of death in Europe, USA and part of Asia. LÄS MER

  7. 5. Folding and retention of rotavirus glycoproteins in the endoplasmic reticulum

    Författare :Ali Mirazimi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ER; rotavirus; VP7; NSP4; oligosaccharide processing; N-linked glycosylation; protein disulfide isomerase; calnexin; ATP; ER retention;

    Sammanfattning : The endoplasmic reticulum (ER) is a membrane bound organelle composed of a network of cisternae stretching throughout the cytoplasm. Functionally, the ER performs many essential processes, such as glycosylation, and biosynthesis of lipids; it provides a redox potential condition for forming S-S linkages, and a quality control system, and functions as an intracellular calcium store. LÄS MER