Sökning: "prion protein PrP"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden prion protein PrP.

  1. 1. Protein Misfolding in Human Diseases

    Författare :Karin Almstedt; Per Hammarström; Daniel Otzen; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Misfolding; carbonic anhydrase; prion protein; protein stability; Biochemistry; Biokemi;

    Sammanfattning : There are several diseases well known that are due to aberrant protein folding. These types of diseases can be divided into three main categories:Loss-of-function diseasesGain-of-toxic-function diseasesInfectious misfolding diseases Most loss-of-function diseases are caused by aberrant folding of important proteins. LÄS MER

  3. 2. Novel endogenous mechanisms of complement regulation - A delicate balance

    Författare :Andreas Holmér; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; short leucine rich glycoprotein; factor H; C1q; age-related macular degeneration; C4b-binding protein; prion disease; prion protein; Complement regulation; C-reactive protein;

    Sammanfattning : In this thesis, the biochemical mechanisms for complement activation by endogenous proteins are explored. The short leucine-rich repeat proteins (SLRPs) help organise extracellular matrices. We found that several SLRPs bind C1q and of these, fibromodulin and osteoadherin trigger complement. LÄS MER

  4. 3. Pulling Force Studies of Secretory Protein Translocation into the Endoplasmic Reticulum

    Författare :Theresa Kriegler; Tara Hessa; Patricia Clark; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Co-translational translocation; Xbp1 arrest peptide; Translocon-associated protein TRAP complex; Prion protein; Insulin; Biochemistry; biokemi;

    Sammanfattning : More than 30% of human genes encode secretory or membrane proteins. Most secretory proteins are targeted to the Endoplasmic reticulum (ER) membrane via cleavable N-terminal signal sequences either in a co- or post-translational manner. They enter or cross the membrane using a protein translocating channel (translocon). LÄS MER

  5. 4. Interactions of Prion Proteins and PrP-derived Peptides in Scrapie infection

    Författare :Kajsa Löfgren Söderberg; Astrid Gräslund; Marcus Fändrich; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Spongiform encephalopathy; Creutzfeldt-Jakob disease; Amyloidosis; Neurodegeneration; Cell penetrating peptide; Protein Transduction Domain; Heparan sulfate; Proteoglycan; Glypican; Src family kinase; Fyn; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : Prion diseases are fatal and incurable spongiform encephalopathies that occur amongst mammals. The central pathological event is the misfolding of the cellular prion protein (PrPC) into an amyloid, neurotoxic isoform called scrapie (PrPSc). PrPSc is the main, or sole, constituent of infectious prions. LÄS MER

  7. 5. Biophysical studies of membrane interacting peptides derived from viral and Prion proteins

    Författare :Kamila Oglęcka; Astrid Gräslund; Stephen White; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Prion peptides; Doppel peptide; Influenza fusion peptides; peptide-membrane interactions; translocation; linear dichroism; circular dichroism; Biophysics; Biofysik; Biophysics; biofysik;

    Sammanfattning : This thesis focuses on peptides derived from the Prion, Doppel and Influenza haemagglutinin proteins in the context of bilayer interactions with model membranes and live cells. The studies involve spectroscopic techniques like fluorescence, fluorescence correlation spectroscopy (FCS), circular and linear dichroism (CD and LD), confocal fluorescence microscopy and NMR. LÄS MER