Sökning: "prepubertal"

Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet prepubertal.

  1. 1. Identification of novel growth hormone-regulated factors

    Författare :Björn Andersson; Göteborgs universitet; []
    Nyckelord :Growth hormone; idiopathic short stature; growth hormone deficient; prepubertal; children; genomic; proteomic;

    Sammanfattning : The studies described in this thesis aimed to identify novel factors involved in the regulation of longitudinal growth and bone mineralization in response to growth hormone (GH) treatment. This was done by performing a single factor study (Paper I) where it was found that growth response was negatively correlated with adiponectin levels during the first year of GH treatment in short prepubertal children. LÄS MER

  3. 2. Ancestral influences on health of grandchildren

    Författare :Gunnar Kaati; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The late effects in adulthood of nutrition during adolescence, childhood, infancy, and the fetal and embryonic stages of development have attracted much attention in research, but less so the time of development of the genome. The issue of fetal origins of adult disease has particularly attracted interest. LÄS MER

  4. 3. Severe childhood obesity : behavioural and pharmacological treatment

    Författare :Pernilla Danielsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Childhood obesity is a chronic disease associated with increased morbidity, psychosocial problems and reduced life expectancy, all of which is today very common. Despite this, long-term studies of behavioural treatment of childhood obesity are currently lacking. LÄS MER

  5. 4. Testosterone and 17beta-oestradiol secretions in children and adolescents. Assay development, levels for comparison and clinical applications

    Författare :Carina Ankarberg-Lindgren; Göteborgs universitet; []
    Nyckelord :17beta-oestradiol; testosterone; sensitive assay; data for comparison; prepuberty; puberty; children; pubertal induction.;

    Sammanfattning : Accurate measurements of 17beta-oestradiol and testosterone are important in clinical settings of pubertal disorders and hormone replacement therapy among children. Most assays for measurement of these steroids are optimised for fertility investigations in adults and are not sensitive enough for quantification in children. LÄS MER

  7. 5. Metabolic responsiveness to growth hormone in children

    Författare :Ralph Decker; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Individualized treatment; Growth hormone; Hormonal responsiveness; Metabolic outcome; Prediction model; Body composition; Insulin sensitivity; Leptin; Proteomics SELDI; Apolipoproteins; Thresholds of growth hormone effects; Protein patterns;

    Sammanfattning : Metabolic effects of growth hormone (GH) therapy in short children have not been clearly established owing to the previous lack of controlled trials studying the metabolic outcome in response to different GH doses despite the known effects of GH on insulin sensitivity, lipid profile, and body composition. It has previously been shown that individualized GH doses during catch-up growth significantly reduce the proportion of unexpectedly good and poor responders around a predefined individual growth target in short prepubertal children. LÄS MER