Sökning: "preclinical assay"

Visar resultat 1 - 5 av 31 avhandlingar innehållade orden preclinical assay.

1. 1. Preclinical tumor-immune modeling : For the identification of immunomodulatory drugs

   Författare :Tove Selvin; Mårten Fryknäs; Rolf Larsson; Claes Andersson; Malin Jarvius; Brinton Seashore-Ludlow; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; anti-cancer drugs; preclinical modeling; drug screening; repurposing;

   Sammanfattning : For a long time, the field of cancer research was dominated by a tumor cell-centric view. That, however, changed once it became recognized that medical cancer treatment is largely influenced by the combined effect exerted on both cancer and immune cells. LÄS MER

3. 2. Development of sensitive cellular assay systems and their application to the identification of "orphan" seven-transmembrane receptors

   Författare :Knut Kotarsky; Slemhinnans immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biokemi; Metabolism; Biochemistry; metabolism; leukotrieneB4; thiazolidinedione; 9-HODE; fatty acid; luciferase; GFP; reporter gene; preclinical assay; receptor; GPCR;

   Sammanfattning : Seven-transmembrane, G-protein coupled receptors play a central role in physiology since they facilitate cell communication in multicellular organisms by recognition of a broad range of ligands. They also represent important drug targets. LÄS MER

4. 3. Circumventing drug resistance : Studies exploring the expediency of a total cell kill chemoresistance assay

   Författare :Bertil Jonsson; Uppsala universitet; []
   Nyckelord :Medical sciences; drug resistance; drug resistance assay; clinical correlations; cancer; human; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

   Sammanfattning : Cellular resistance to anti-cancer drugs is considered to be the major cause of treatment failure in clinical practice. The present studies have therefore focused on ways to circumvent resistance as evaluated by an in vitro chemoresistance assay. LÄS MER

5. 4. Feasibility of the fluorometric microculture cytotoxicity assay (FMCA) in the preclinical evaluation of anticancer drugs

   Författare :Helena Fridborg; Uppsala universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : .... LÄS MER

7. 5. Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications

   Författare :Caroline Haglund; Elin Lindhagen; Rolf Larsson; Anna Åleskog; Sigurd Vitols; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anticancer drugs; In vitro assays; Toxicity testing; Haematological toxicity; Primary tumour cells; Species difference; Clinical pharmacology; Klinisk farmakologi; Clinical Pharmacology; Klinisk farmakologi;

   Sammanfattning : Preclinical testing is an important part of cancer drug development. The aim of this thesis was to establish and evaluate preclinical in vitro methods useful in the development of new anticancer drugs. In paper I, the development of non-clonogenic assays (FMCA-GM) using CD34+ stem cells for assessment of haematological toxicity was described. LÄS MER