Sökning: "pore-forming toxins"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden pore-forming toxins.
1. Studies of pore-forming bacterial protein toxins in Escherichia coli
Sammanfattning : Escherichia coli, a Gram-negative bacterium, which can be classified into three groups: the commensal, intestinal pathogenic (IPEC) and extra-intestinal pathogenic (ExPEC) E. coli. The cytolysin A (ClyA) protein, a 34-kDa pore-forming toxin, encoded by a gene found in both non-pathogenic and pathogenic E. LÄS MER
2. Pathogen entry mechanisms and endocytic responses to plasma membrane damage
Sammanfattning : Endocytosis is a fundamental cellular process by which cells transport material from the outside to the inside of the cell through the formation of membrane invaginations that bud off from the plasma membrane. This process is important for nutrient uptake, regulating cell surface receptors and the overall plasma membrane composition. LÄS MER
3. Novel signaling pathways : induced by bacterial toxins in eukaryotic cells
Sammanfattning : Inflammation is the process by which the host counteracts microbes that are constantly exposing the human body. These microbes rarely cause disease, due to the effective defense mechanisms of the host immune system. Although inflammation is essential for preventing infections, it can also damage the host. LÄS MER
4. Effects of bacterial toxins on calcium homeostasis in renal inflammation
Sammanfattning : Calcium (Ca2+) is a highly versatile ion used for intra- and inter-cellular signalling in eukaryotic cells, and numerous cellular events are regulated by alteration of the intracellular Ca2+ concentration. We hypothesized that bacterial virulence factors may alter the Ca 2+ homeostasis in epithelial cells such that the innate immune response is affected. LÄS MER
5. Neutrophil interactions with Streptococcus pyogenes and Staphylococcus aureus
Sammanfattning : Streptococcus pyogenes and Staphylococcus aureus are Gram-positive bacteria that share many features, including clinical presentations and pathogenic mechanisms, and yet, they still have unique properties. They both cause diseases ranging from uncomplicated infections to severe invasive diseases, such as sepsis and toxic shock syndrome, as well as severe tissue infections including necrotizing fasciitis and necrotizing pneumonia. LÄS MER