Sökning: "polyclonal antibody"

Visar resultat 11 - 15 av 55 avhandlingar innehållade orden polyclonal antibody.

  1. 11. Validation of antibodies for protein profiling : A study using immunohistochemistry on tissue microarrays

    Författare :Linda Paavilainen; Fredrik Pontén; Ola Nilsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody validation; monospecific antibodies; protein profiling; immunohistochemistry; tissue microarrays; western blot; fixatives; Pathology; Patologi; Pathology; patologi;

    Sammanfattning : The field of proteomics has rapidly expanded due to the completion of the human genome sequence. This thesis validates affinity-purified monospecific antibodies of polyclonal origin, for protein profiling in a broad spectrum of normal tissues and cells. LÄS MER

  3. 12. Virus mediated induction of antibody independent cytotoxicity (VDCC) and enhancement of antibody dependent cytotoxicity (ADCC) in human lymphocytes in vitro

    Författare :Abdul-Razzak Alsheikhly; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Addition in vitro of small amounts of paramyxoviruses (Mumps or Sendai) to lymphocytes from healthy human donors induces a strong and non-selective cytotoxicity against a variety of target cells (VDCC, virus dependent cellular cytotoxicity). VDCC-like reactions are believed to play a role in vivo in the defense against virus infection and/or the causation of the tissue lesions associated with virus disease. LÄS MER

  4. 13. HIV-1 infection and loss of serological memory : the role of altered expression of B-cell chemokine receptors, timing of HAART and impaired antibody affinity maturation

    Författare :Alberto Cagigi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Currently, big efforts in HIV-1 research are devoted to the design of a HIV-1 vaccine. However, no successful vaccine is yet available, also due to the lack of basic knowledge in HIV-1 pathogenesis which is still profound. LÄS MER

  5. 14. Immunochemical, biochemical and evolutionary studies on Micrurus nigrocinctus nigrocinctus venom toxins

    Författare :Alberto Alape-Girón; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Monoclonal antibody; Phospholipase A2; neurotoxin; myotoxin; protein evolution;

    Sammanfattning : Immunochemical, biochemical and evolutionary studies on Micrurus nigrocinctus nigrocinctus venom toxins Monoclonal antibodies (MAbs) were produced against venom proteins of M. nigrocinctus nigrocinctus, the medically most important elapid of Central America. LÄS MER

  7. 15. Allergy to laboratory animals : risk factors for development of allergy and methods for measuring airborne rodent allergens

    Författare :Anne Renström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :laboratory animal allergy; atopy; IgE; methacholine provocation; aeroallergen measurement; ELISA; monoclonal antibody; Mus m 1; Rat n 1;

    Sammanfattning : Between 10-50% of workers exposed to laboratory animals, mainly rats or mice, develop laboratory animal allergy (LAA) with symptoms of rhinitis, conjuctivitis, asthma, or urticaria, and IgE against animal allergens. Symptoms often arise within the first years of animal work. Up to half of the symptomatic subjects develop asthma. LÄS MER