Sökning: "platelet-derived growth factor receptor"
Visar resultat 1 - 5 av 95 avhandlingar innehållade orden platelet-derived growth factor receptor.
1. Functions of platelet-derived growth factor-A during organogenesis
Sammanfattning : The formation of organs during embryonic development is calledorganogenesis. This process is regulated by the genes residing in the genome. LÄS MER
2. Platelet-derived growth factor-induced signal transduction
Sammanfattning : Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells, elicits its effects by binding to cell surface tyrosine kinase receptors, denoted α- and β-receptors. This thesis describes the mechanism of interaction between stimulated PDGF receptors and various intracellular molecules. LÄS MER
3. Regulation of the platelet-derived growth factor β-receptor
Sammanfattning : Growth factors are important signalling molecules, regulating cell growth, as well as cell movement, differentiation and apoptosis. They bind to specific receptors on the cell surface causing activation of the receptors. Activated receptors then attract adaptor molecules that brings the signal further into the cell. LÄS MER
4. Pericyte recruitment and functions in vivo. Studies of platelet-derived growth factor-B deficient embryos
Sammanfattning : A functional vascular system is essential for tissue growth and maintenance, and the circulatory system is therefore the first operational organ of the vertebrate embryo. In conditions of pathological tissue growth, such as tumors, formation of new blood vessels is also required, and it is anticipated that prevention of blood vessel development in those settings might ameliorate the disease progress. LÄS MER
5. Transcriptional Regulation of the Platelet-Derived Growth Factor beta-receptor
Sammanfattning : The Platelet Derived-Growth Factor (PDGF) receptors and ligands are expressed in cells of predominantly mesenchymal origin. Binding of the ligands to the receptors stimulates cell proliferation and other cellular responses such as differentiation and cell movement. LÄS MER