Sökning: "phenobarbital"

Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet phenobarbital.

  1. 1. Regulation of Vitamin D 25-hydroxylases : Effects of Vitamin D Metabolites and Pharmaceutical Compounds on the Bioactivation of Vitamin D

    Författare :Maria Ellfolk; Kjell Wikvall; Maria Norlin; Olavi Pelkonen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP2D25; vitamin D 25-hydroxylase; transcriptional regulation; vitamin D; CYP2R1; CYP2J2; CYP27A1; phenobarbital; efavirenz; fibroblast; LNCaP; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Sammanfattning : A 700bp portion of the promoter of CYP2D25, the porcine microsomal vitamin D 25-hydroxylase was isolated and sequenced. The computer analysis of the sequence revealed the existence of a putative VDRE at 220 bp upstream of the transcription start site. LÄS MER

  3. 2. The attenuation of the P53 response to DNA damage in rodent liver preneoplastic enzyme-altered foci

    Författare :Niklas Finnberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Enzyme-altered foci; p53; ATM; diethylnitrosamine; phenobarbital; liver; gene dosage;

    Sammanfattning : In connection with life-time bioassays in rodents, the liver is one of the organs most frequently affected. During the carcinogenic process, single preneoplastic hepatocytes develop into hepatocellular adenoma or carcinoma (HCC). LÄS MER

  4. 3. New approaches for treatment of acute intermittent porphyria by enzyme substitution and gene therapy : evaluation in vitro and in vivo

    Författare :Annika Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acute intermittent porphyria; adenovirus; 5-aminolevulinic acid; enzyme substitution; gene therapy; non-viral gene delivery; porphobilinogen; porphobilinogen deaminase; protoporphyrin;

    Sammanfattning : Acute intermittent porphyria (AIP) is a rare inborn metabolic error of heme synthesis in which the activity of the third enzyme, porphobilinogen deaminase (PBGD), is deficient. It is clinically characterized by acute, potentially life-threatening neurologic attacks that are precipitated by various drugs, reproductive hormones and other factors. LÄS MER

  5. 4. Cytochrome P450 Enzymes in the Metabolism of Vitamin D3

    Författare :Fardin Hosseinpour; Leif Bertilsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Biochemistry; biokemi;

    Sammanfattning : A cytochrome P450 enzyme in pig kidney that catalyzes the hydroxylations of vitamin D3 and C27-sterols was cloned. DNA sequence analysis of the cDNA revealed that the enzyme belongs to the CYP27 family. The recombinant kidney CYP27A enzyme catalyzed the 25-hydroxylation of vitamin D3 and the 27-oxygenation of C27-sterols. LÄS MER

  7. 5. Cytochrome P-450 in Drosophila melanogaster : activity, genetic variation and regulation

    Författare :Inger Porsch-Hällström; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The cytochrome P-450 enzyme system in the fruit fly, Drosophila melanogaster, was shown to be inducible, to consist of several isozymes and to have the capacity to metabolize a variety of substrates, thus resembling the corresponding mammalian system. These similarities strengthens the value of Drosophila test systems for the detection of indirect carcinogens and mutagens. LÄS MER