Sökning: "phagocyte oxidase"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden phagocyte oxidase.

  1. 1. Activation of professional phagocytes with emphasis on the formyl peptide receptor family

    Författare :Jennie Karlsson; Göteborgs universitet; []
    Nyckelord :phagocyte; G-protein coupled receptor; chemoattractant; formyl peptide receptor; reactive oxygen species; calcium;

    Sammanfattning : Phagocytic cells such as neutrophil granulocytes and monocytes are an essential part of our innate immune system and play an important role in the battle against pathogens. G-protein coupled receptors (GPCRs) and more specifically chemoattractant receptors are a vital part in guiding phagocytes towards the site of infection. LÄS MER

  3. 2. Reactive oxygen and nitrogen in host defence against Francisella tularensis

    Författare :Helena Lindgren; Anders Sjöstedt; Tommy Sundquist; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Francisella tularensis; inducible nitric oxide synthase; phagocyte oxidase; macrophages; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; klinisk bakteriologi; Clinical Bacteriology;

    Sammanfattning : Francisella tularensis, the causative agent of tularemia, is a potent human and animal pathogen. Initially upon infection of the host, intramacrophage proliferation of F. tularensis occurs but after activation of the acquired host immunity, the phagocytes become activated to kill the bacterium. In my thesis, I focused on mechanisms utilized by F. LÄS MER

  4. 3. Human mononuclear phagocytes : Production of reactive oxygen species generated by the NADPH oxidase

    Författare :Agneta Johansson; Roger Sundler; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Human professional phagocytes constitute the first line of defence against invading microorganisms. With a membrane-bound enzyme system, the NADPH oxidase, these cells generate bactericidal metabolites. Activation of NADPH oxidase results in a generation of reactive oxygen species, e.g. LÄS MER

  5. 4. Structural Insights into the Acquisition and Storage of Iron

    Författare :Ulrika Schagerlöf; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Strukturkemi; Molecular biophysics; Molekylär biofysik; Structure chemistry; single particle; ferric reductase; human phagocyte superoxide-generating NADPH oxidase; frataxin; cryo electron microscopy; FRO2; iron homeostasis; iron acquisition;

    Sammanfattning : It is of vital importance to understand the systems for iron metabolism and this thesis contributes to this by providing insights into the structure and function of the acquisition and homeostasis of iron. The two proteins that have been primarily investigated are a ferric reductase from Arabidopsis thaliana called FRO2 and a mitochondrial iron chaperone from Saccharomyces cerevisiae called frataxin. LÄS MER

  7. 5. The Role of Reactive Oxygen Species in Animal Models of Autoimmunity

    Författare :Malin Hultqvist; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mice; Phytol; ROS; NOX; NADPH; p47phox; Ncf1; EAE; inflammation; Arthritis; RA; MS; Rats; Autoimmunity;

    Sammanfattning : Reactive oxygen species (ROS) produced by the phagocyte NADPH oxidase complex are important in the killing of invading pathogens. Lately, a role of ROS has been suggested in regulation of the immune system. LÄS MER